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Details for Patent: 4,292,326

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Details for Patent: 4,292,326

Title: Process for treatment of hyperpigmentary dermatoses
Abstract:There is disclosed a composition for the treatment of acne, hyperpigmentary dermatoses or skin hyperpigmentation which contains dicarboxylic acids containing 7 to 13 carbon atoms or certain derivatives thereof that contain reducing functional group or a salt thereof. There are also disclosed methods for preparing mercapto derivatives of these dicarboxylic acids.
Inventor(s): Nazzaro-Porro; Marcella (Rome, IT)
Assignee:
Filing Date:Dec 01, 1978
Application Number:05/965,584
Claims:1. A method for the treatment of individuals exhibiting noncancerous or non-precancerous hyperpigmentary dermatoses which comprises administering to said individual a therapeutically effective amount of an active ingredient in a pharmaceutically acceptable carrier until said condition is reduced or its further development is arrested wherein said active ingredient is at least one dicarboxylic acid containing from 7 to 13 carbon atoms or a mono or dimercapto derivative of said acid or a salt thereof.

2. A method as defined in claim 1 wherein said dicarboxylic acid is selected from the group consisting of pimelic acid, suberic acid, sebacic acid, azelaic acid, 1,9-nonanedicarboxylic acid, 1,10-decanedicarboxylic acid, and 1,11-undecanedicarboxylic acid.

3. A method as defined in claim 1 wherein said individual exhibits a chloasma condition.

4. A method as defined in claim 1 wherein said individual exhibits a poikiloderma of Civatte condition.

5. A method as defined in claim 1 wherein said acid is administered orally.

6. A method as defined in claim 1 wherein said acid is administered by injection.

7. A method as defined in claim 1 wherein said acid is administered topically.

8. A method as defined in claim 1 wherein said dicarboxylic acid is azelaic acid.

9. A method as defined in claim 1 wherein said dicarboxylic acid is 1,10-decanedicarboxylic acid.
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