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Details for Patent: 4,279,819

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Details for Patent: 4,279,819

Title: Aminoalkyl furan derivatives
Abstract:Compounds of the general formula I: ##STR1## and physiologically acceptable salts thereof and N-oxides and hydrates, in which R.sub.1 and R.sub.2 which may be the same or different represent hydrogen, lower alkyl, cycloalkyl, lower alkenyl, aralkyl or lower alkyl interrupted by an oxygen atom or a group ##STR2## in which R.sub.4 represents hydrogen or lower alkyl or R.sub.1 and R.sub.2 may, together with the nitrogen atom to which they are attached, form a heterocyclic ring which may contain other heteroatoms selected from O and ##STR3## R.sub.3 is hydrogen, lower alkyl, lower alkenyl or alkoxyalkyl; X is --CH.sub.2 --, O or S; Y represents .dbd.S, .dbd.O, .dbd.NR.sub.5 or .dbd.CHR.sub.6 ; Alk denotes a straight or branched alkylene chain of 1 to 6 carbon atoms; R.sub.5 is H, nitro, cyano, lower alkyl, aryl, alkylsulphonyl, or arylsulphonyl; R.sub.6 represents nitro, arylsulphonyl or alkylsulphonyl; m is an integer from 2 to 4; and n is 1 or 2; or when X.dbd.S, or --CH.sub.2 --, n is zero, 1 or 2. These compounds have H.sub.2 -antagonist activity. Intermediates in the production thereof are also provided.
Inventor(s): Price; Barry J. (Hertford, GB2), Clitherow; John W. (Sawbridgeworth, GB2), Bradshaw; John (Ware, GB2)
Assignee: Allen & Hanburys Ltd. (GB2)
Filing Date:Oct 13, 1978
Application Number:05/951,025
Claims:1. A compound of the formula ##STR41## wherein R.sub.1 and R.sub.2 independently represent hydrogen, alkyl of 1 to 3 carbon atoms or phenethyl;

X is --S--;

Alk denotes methylene;

m is 2 or 3; and

n is 1.

2. A compound of the formula ##STR42## in which R.sub.1 and R.sub.2 together with the nitrogen atom to which they are attached form a morpholinyl, piperidinyl, pyrrolidinyl, or N-alkylpiperazinyl group;

X is --CH.sub.2 --, --O-- or --S--;

Alk denotes a straight or branched alkylene chain of 1 to 6 carbon atoms;

m is an integer from 2 to 4; and

n is 1 or 2; or when X is --S-- or --CH.sub.2 --, n is zero, 1 or 2.

3. A compound as claimed in claim 2 in which R.sub.1 and R.sub.2 together with the nitrogen atom to which they are attached form a pyrrolidinyl group.

4. A compound as claimed in claim 3 in which Alk denotes methylene; m is 2 or 3 and n is 1.

5. The compound of claim 2 which is 2-[[[5-(1-pyrrolidino)methyl-2-furanyl]methyl]thio]-ethanamine.

6. The compound of claim 1 which is 2-[[[5-(dimethylamino)methyl-2-furanyl]methyl]thio]-ethanamine.

7. The compound of claim 1 which is 2-[[[5-(methylamino)methyl-2-furanyl]methyl]thio]-ethanamine.

8. The compound of claim 1 which is 2-[[[5-(diethylaminomethyl)-2-furanyl]methyl]thio]-ethanamine.

9. The compound of claim 1 which is 2-[[[5-(ethylmethylamino)methyl-2-furanyl]methyl]thio]-ethanamine.
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