Generated: May 25, 2017
|Title:||Treating cardiac arrhythmias|
|Abstract:||Fluorenes bearing a 9-aminoalkyl substituent are useful antiarrhythmic agents. Pharmaceutical formulations containing such compounds are provided, as well as a method of treatment.|
|Inventor(s):||Lacefield; William B. (Indianapolis, IN), Simon; Richard L. (Greenwood, IN)|
|Assignee:||Eli Lilly and Company (Indianapolis, IN)|
|Filing Date:||Apr 17, 1980|
|Claims:||1. A method for treating cardiac arrhythmias comprising administering to a subject suffering from an arrhythmia and in need of treatment or to a subject suspected of being prone toward developing a cardiac arrhythmia and in need of prophylactic treatment an antiarrhythmic amount of a compound of the formula ##STR12## wherein: n is 3, 4 or 5; |
R.sup.2 and R.sup.3 independently are hydrogen, C.sub.1 -C.sub.6 alkyl, CH.sub.2 C.sub.2 -C.sub.5 alkenyl, phenyl-C.sub.1 -C.sub.3 alkyl, or taken together with the nitrogen to which they are attached are a cyclic group of the formula ##STR13## in which R.sup.8 is hydrogen or C.sub.1 -C.sub.4 alkyl; A is CH.sub.2, O or NH; and y is zero or one;
R.sup.6 and R.sup.7 independently are hydrogen, C.sub.1 -C.sub.4 alkyl or halogen;
and the pharmaceutically acceptable salts thereof.
2. The method of claim 1 which employs a compound wherein R.sup.8 is C.sub.1 -C.sub.4 alkyl.
3. The method of claim 2 which employs a compound wherein R.sup.2 is hydrogen or C.sub.1 -C.sub.6 alkyl.
4. The method of claim 3 which employs a compound wherein R.sup.6 and R.sup.7 both are hydrogen.
5. The method of claim 4 which employs a compound wherein R.sup.3 is C.sub.1 -C.sub.6 alkyl.
6. The method of claim 1 which employs a compound wherein n is 3.
Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verifification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.