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|Title:||Process for preparing polycyclic heterocycles having a pyran ring|
|Abstract:||A process applicable to the preparation of a wide variety of novel polycyclic heterocycles having a newly-formed pyran ring is disclosed. According to the process an aromatic nucleus bearing an ethanol group, for example, 3,4-dimethoxyphenethyl alcohol, is condensed with an aldehyde or ketone or a protected aldehyde or ketone, for example, aminoactaldehyde diethyl acetal, in the presence of an acid catalyst to afford the polycyclic heterocycle, for example, 6,7-dimethoxy-1-isochromanmethylamine. The new heterocycles so formed are useful for preparing derivatives having antiinflammatory, antibacterial or antifungal activities.|
|Inventor(s):||Dobson; Thomas A. (Dollard des Ormeaux, CA), Humber; Leslie G. (Dollard des Ormeaux, CA), Demerson; Christopher A. (St. Laurent, CA), Jirkovsky; Ivo L. (Montreal, CA)|
|Assignee:||American Home Products Corporation (New York, NY)|
|Filing Date:||Feb 03, 1977|
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