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Details for Patent: 4,207,241

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Details for Patent: 4,207,241

Title: 2-Naphthyl acetic acid derivatives and compositions and methods thereof
Abstract:2-Naphthyl acetic acid derivatives and the corresponding amides, esters, hydroxamic acids and addition salts thereof, optionally substituted at the .alpha.-position on the acetic acid moiety and/or at position 6 and/or at positions 1, 4, 7 or 8 on the naphthyl ring and optionally saturated at positions 3 and 4, are anti-inflammatory, analgesic, antipyretic and anti-pruritic agents. A pharmaceutical method of effecting treatment of inflammation, pain, pyrexia and pruritus by the administration of naphthyl acetic acid derivatives. A pharmaceutical composition for use in the treatment of the above maladies comprising a naphthyl acetic acid derivative.
Inventor(s): Fried; John H. (Palo Alto, CA), Harrison; Ian T. (Palo Alto, CA)
Assignee: Syntex Corporation (Palo Alto, CA)
Filing Date:Mar 27, 1978
Application Number:05/890,421
Claims:1. A compound of the formula ##STR9## wherein R.sup.7 is methoxy, methoxymethyloxy, difluoromethoxy, 4'-methoxytetrahydropyran-4'yloxy, methylthio, methoxymethylthio, or difluoromethylthio;

R.sup.10 and R.sup.11 taken together are methylene or difluoromethylene;

and the corresponding alkyl esters and pharmaceutically acceptable acid addition salts thereof.
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