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Serving 500+ biopharmaceutical companies globally:

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Generated: June 24, 2017

DrugPatentWatch Database Preview

Details for Patent: 4,202,979

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Details for Patent: 4,202,979

Title: 6-Ethyl(or allyl)-8-methoxymethyl or methylmercaptomethylergolines and related compounds
Abstract:6-n-Propyl (ethyl or allyl)-8.beta.-methoxy-(methylsulfinyl, methylsulfonyl, or methylmercapto) methylergolines, 8-ergolenes or 9-ergolenes, useful as prolactin inhibitors and in the treatment of Parkinsonism.
Inventor(s): Kornfeld; Edmund C. (Indianapolis, IN), Bach; Nicholas J. (Indianapolis, IN)
Assignee: Eli Lilly and Company (Indianapolis, IN)
Filing Date:Jan 11, 1979
Application Number:06/002,514
Claims:1. A compound of the formula ##STR3## wherein Y is O, SO, SO.sub.2 or S, R.sup.1 is ethyl, or allyl, X is H, Cl or Br and R.sup.2, R.sup.3 and R.sup.4 when taken singly are hydrogen, and R.sup.2 and R.sup.3, and R.sup.3 and R.sup.4, when taken together with the carbon atoms to which they are attached, form a double bond, and pharmaceutically-acceptable acid addition salts thereof.

2. A compound according to claim 1 in which Y is S and R.sup.1 is ethyl or allyl.

3. A compound according to claim 1 in which Y is S, X is H and R.sup.1 is ethyl or allyl.

4. A compound according to claim 1, said compound being D-6-ethyl-8.beta.-methylmercaptomethylergoline mesylate.

5. A compound according to claim 1, said compound being D-6-allyl-8-methylmercaptomethylergoline mesylate.
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Serving 500+ biopharmaceutical companies globally:

Express Scripts
US Department of Justice
Harvard Business School

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