|Title:||6-Ethyl(or allyl)-8-methoxymethyl or methylmercaptomethylergolines and related compounds|
|Abstract:||6-n-Propyl (ethyl or allyl)-8.beta.-methoxy-(methylsulfinyl, methylsulfonyl, or methylmercapto) methylergolines, 8-ergolenes or 9-ergolenes, useful as prolactin inhibitors and in the treatment of Parkinsonism.|
|Inventor(s):||Kornfeld; Edmund C. (Indianapolis, IN), Bach; Nicholas J. (Indianapolis, IN)|
|Assignee:||Eli Lilly and Company (Indianapolis, IN)|
|Filing Date:||Jan 11, 1979|
|Claims:||1. A compound of the formula ##STR3## wherein Y is O, SO, SO.sub.2 or S, R.sup.1 is ethyl, or allyl, X is H, Cl or Br and R.sup.2, R.sup.3 and R.sup.4 when taken singly are hydrogen, and R.sup.2 and R.sup.3, and R.sup.3 and R.sup.4, when taken together with the carbon atoms to which they are attached, form a double bond, and pharmaceutically-acceptable acid addition salts thereof. |
2. A compound according to claim 1 in which Y is S and R.sup.1 is ethyl or allyl.
3. A compound according to claim 1 in which Y is S, X is H and R.sup.1 is ethyl or allyl.
4. A compound according to claim 1, said compound being D-6-ethyl-8.beta.-methylmercaptomethylergoline mesylate.
5. A compound according to claim 1, said compound being D-6-allyl-8-methylmercaptomethylergoline mesylate.
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