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Details for Patent: 4,183,938

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Details for Patent: 4,183,938

Title: 1,8-Ethano-5-oxo-octa- and -decahydroquinolines and mydriatic compositions thereof
Abstract:Compounds of the general formula: ##STR1## wherein X is selected from the group consisting of oxygen, CH.sub.2 and CH radicals, and when X designates oxygen, R designates alkyl, isoalkyl, aralkyl, and substituted aralkyl groups and when X designates CH.sub.2 then R designates alkyl, phenyl or substituted phenyl group, and A-B is a single bond, and when X designates CH.sub.2 R designates alkyl, phenyl or substituted phenyl groups and A-B is a double bond; and physiologically acceptable salts of these, and mydriatic pharmaceutical compositions containing the same as active ingredient.
Inventor(s): Cohen; Sasson (Tel-Aviv, IL), Fisher; Abraham (Holon, IL)
Assignee: The Purdue Frederick Company (NY)
Filing Date:Nov 17, 1977
Application Number:05/852,402
Claims:1. A compound of the formula: ##STR8## wherein X is selected from the group consisting of CH.sub.2 and CH, wherein when X is CH.sub.2 then A-B is a single bond and wherein when X is CH then A-B is a double bond and wherein R is selected from the group consisting of lower alkyl, cyclopentyl, cyclohexyl, thienyl, phenyl, methylphenyl, methoxyphenyl, chlorophenyl, trifluoromethylphenyl, aminophenyl, di-loweralkylamino phenyl and benzyl, and physiologically acceptable salts thereof.

2. A compound of claim 1, 1,8-ethano5-oxo-4-phenyl-1,10,9,8,5,4,3,2-octahydroquinoline and its physiologically acceptable salts.

3. A compound of claim 1, 1,8-ethano-5-oxo-4-phenyl-decahydroquinoline and its physiologically acceptable salts.

4. A compound of claim 1, 1,8-ethano-5-oxo-4-ethyldecahydroquinoline and its physiologically acceptable salts.

5. A pharmaceutical preparation for use as a mydriatic, comprising a mydriatic effective amount of the compound of claim 1 dissolved in a solvent therefor which is pharmaceutically acceptable therefor.
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