|Abstract:||Novel N-(4-piperidinyl)-N-phenylamides and -carbamates having very potent analgesic activity, methods of preparing same and useful intermediates therefor.|
|Inventor(s):|| Janssen; Paul A. J. (Vosselaar, BE), Van Daele; Georges H. P. (Turnhout, BE) |
|Assignee:|| Janssen Pharmaceutica N.V. (Beerse, BE) |
|Filing Date:||Dec 19, 1977|
|Claims:||1. A compound selected from the group consisting of a piperidine derivative having the formula: ##STR102## and the stereochemical optical isomeric forms thereof, wherein: Z is a member selected from the group consisting of hydrogen, halo, lower alkyl, lower alkyloxy and trifluoromethyl; |
X is a member selected from the group consisting of hydrogen and methyl;
L.sup.2 is a member selected from the group consisting of alkyl having from 3 to 10 carbons and lower alkenyl; and
R.sup.13 is a carboxylate radical represented by the formula: ##STR103## wherein R.sup.2 is a member selected from the group consisting of lower alkyl, lower alkenyl and phenylmethyl.
2. Ethyl 1-(1-methylethyl)-4-(phenylamino)-4-piperidinecarboxylate.
3. Methyl 1-(1-methylethyl)-4-phenylamino)-4-piperidinecarboxylate.