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Fish and Richardson
Express Scripts
Cantor Fitzgerald
Harvard Business School

Generated: January 21, 2018

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Title: N-(4-piperidinyl)-N-phenylamides
Abstract:Novel N-(4-piperidinyl)-N-phenylamides and -carbamates having very potent analgesic activity, methods of preparing same and useful intermediates therefor.
Inventor(s): Janssen; Paul A. J. (Vosselaar, BE), Van Daele; Georges H. P. (Turnhout, BE)
Assignee: Janssen Pharmaceutica N.V. (Beerse, BE)
Filing Date:Dec 19, 1977
Application Number:05/862,073
Claims:1. A compound selected from the group consisting of a piperidine derivative having the formula: ##STR102## and the stereochemical optical isomeric forms thereof, wherein: Z is a member selected from the group consisting of hydrogen, halo, lower alkyl, lower alkyloxy and trifluoromethyl;

X is a member selected from the group consisting of hydrogen and methyl;

L.sup.2 is a member selected from the group consisting of alkyl having from 3 to 10 carbons and lower alkenyl; and

R.sup.13 is a carboxylate radical represented by the formula: ##STR103## wherein R.sup.2 is a member selected from the group consisting of lower alkyl, lower alkenyl and phenylmethyl.

2. Ethyl 1-(1-methylethyl)-4-(phenylamino)-4-piperidinecarboxylate.

3. Methyl 1-(1-methylethyl)-4-phenylamino)-4-piperidinecarboxylate.
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Serving leading biopharmaceutical companies globally:

Boehringer Ingelheim
Daiichi Sankyo
US Army
Argus Health

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