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Generated: October 23, 2017

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Title: Phenoxy-amino-propanols
Abstract:New phenoxy-amino-propanols of formula ##STR1## wherein R.sup.1 is alkenyl, alkynyl, alkoxyalkyl or alkenyloxyalkyl with 2-6 C atoms in each case or cycloalkyl with 3-8 C atoms; and R.sup.2 is alkyl or hydroxyalkyl with 1-6 C atoms in each case, cycloalkyl with 3-8 C atoms, aralkyl or aralkyl wherein the aryl radical is mono- to tri-substituted by alkyl, alkoxy, OH, F and/or Cl or mono-substituted by methylenedioxy, with a total of 7-15 C atoms in each case, and the physiologically acceptable acid addition salts thereof, exhibit various pharmacological properties including isoprenaline-antagonism on the heart rate and blood pressure.
Inventor(s): Jonas; Rochus (Darmstadt, DE), Becker; Karl-Heinz (Darmstadt, DE), Enenkel; Hans-Joachim (Darmstadt, DE), Minck; Klaus (Darmstadt, DE), Schliep; Hans-Jochen (Darmstadt, DE)
Assignee: Merck Patent Gesellschaft mit beschrankter Haftung (Darmstadt, DE)
Filing Date:Oct 04, 1977
Application Number:05/839,487
Claims:1. Phenoxy-amino-propanols of the formula ##STR4## wherein R.sup.1 is alkenyl, alkynyl, alkoxyalkyl, alkenyloxyalkyl, with 2-6 C atoms in each case, or cycloalkyl with 3-8 C atoms; and R.sup.2 is aralkyl wherein the aryl radical is monosubstituted by methylenedioxy, with a total of 7-15 C atoms, and the physiologically acceptable acid addition salts thereof.

2. A pharmaceutical composition which comprises an amount of a compound of claim 1 effective for achieving isoprenaline-antagonism on the heart rate or blood pressure, and a pharmaceutically acceptable adjuvant.

3. A method of achieving isoprenaline-antagonism on the heart rate or blood pressure in a mammal, which comprises administering to a mammal an amount of a compound of claim 1 which is effective for achieving isoprenaline-antagonism on the heart rate or blood pressure.

4. 1-(o-2-Methoxyethoxymethyl-phenoxy)-3-[2-(3,4-methylenedio xyphenyl)-ethylamino]-propan-2-ol, a compound of claim 1.

5. A pharmaceutical composition which comprises an amount of a compound of claim 4 effective for achieving isoprenaline-antagonism on the heart rate or blood pressure, and a pharmaceutically acceptable adjuvant.

6. A method of achieving isoprenaline-antagonism on the heart rate or blood pressure in a mammal, which comprises administering to a mammal an amount of a compound of claim 4 which is effective for achieving isoprenaline-antagonism on the heart rate or blood pressure.
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Cerilliant
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Teva
Mallinckrodt
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Covington
Johnson and Johnson
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