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Details for Patent: 4,154,942

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Details for Patent: 4,154,942

Title: Certain tetrahydropyridine-2-carboxylic acids and pyrroline-2-carboxylic acids and derivatives thereof
Abstract:New compounds which have the general formula ##STR1## are useful as hypotensive agents.
Inventor(s): Ondetti; Miguel A. (Princeton, NJ), Natarajan; Sehsea I. (Lawrenceville, NJ)
Assignee: E. R. Squibb & Sons, Inc. (Princeton, NJ)
Filing Date:Aug 15, 1978
Application Number:05/933,950
Claims:1. A compound of the formula ##STR12## wherein R and R.sub.2 each is hydrogen or lower alkyl;

R.sub.1 is lower alkanoyl

m and n each is 0 or 1;

and basic salts thereof.

2. A compound as in claim 1 wherein R and R.sub.2 each is hydrogen or lower alkyl; R.sub.1 is lower alkanoyl and m and n each is 0.

3. A compound as in claim 1 wherein R and R.sub.2 each is hydrogen.

4. A compound as in claim 1 wherein R is hydrogen.

5. A compound as in claim 1 wherein n is 1.

6. A compound as in claim 1 wherein m is 0.

7. A compound as in claim 1 wherein m is 1.

8. A compound as in claim 4 wherein R.sup.1 is acetyl.

9. A compound as in claim 3 wherein R.sub.1 is acetyl; m is 0 and n is 1.

10. A compound as in claim 4 wherein R.sub.1 is acetyl; R.sub.2 is methyl; m is 0; and n is 0.

11. A compound as in claim 4 wherein R.sub.1 is acetyl; R.sub.2 is methyl; m and n each is 1.
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