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|Title:||Certain tetrahydropyridine-2-carboxylic acids and pyrroline-2-carboxylic acids and derivatives thereof|
|Abstract:||New compounds which have the general formula ##STR1## are useful as hypotensive agents.|
|Inventor(s):||Ondetti; Miguel A. (Princeton, NJ), Natarajan; Sehsea I. (Lawrenceville, NJ)|
|Assignee:||E. R. Squibb & Sons, Inc. (Princeton, NJ)|
|Filing Date:||Aug 15, 1978|
|Claims:||1. A compound of the formula ##STR12## wherein R and R.sub.2 each is hydrogen or lower alkyl; |
R.sub.1 is lower alkanoyl
m and n each is 0 or 1;
and basic salts thereof.
2. A compound as in claim 1 wherein R and R.sub.2 each is hydrogen or lower alkyl; R.sub.1 is lower alkanoyl and m and n each is 0.
3. A compound as in claim 1 wherein R and R.sub.2 each is hydrogen.
4. A compound as in claim 1 wherein R is hydrogen.
5. A compound as in claim 1 wherein n is 1.
6. A compound as in claim 1 wherein m is 0.
7. A compound as in claim 1 wherein m is 1.
8. A compound as in claim 4 wherein R.sup.1 is acetyl.
9. A compound as in claim 3 wherein R.sub.1 is acetyl; m is 0 and n is 1.
10. A compound as in claim 4 wherein R.sub.1 is acetyl; R.sub.2 is methyl; m is 0; and n is 0.
11. A compound as in claim 4 wherein R.sub.1 is acetyl; R.sub.2 is methyl; m and n each is 1.
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