Generated: May 27, 2017
|Title:||Spiro (1,3-dioxolane-4,3') quinuclidine compounds|
|Abstract:||Novel spiro (1,3-dioxolane-4,3') quinuclidine compounds of the formula ##STR1## wherein R.sub.1 and R.sub.2, which may be identical or different, each designates a member of the group hydrogen, alkyl or aryl; a process for the production of these and pharmaceutical compositions of matter containing such compound as active ingredient.|
|Inventor(s):||Cohen; Sasson (Tel-Aviv, IL), Fisher; Abraham (Holon, IL)|
|Assignee:||The Purdue Frederick Company (Norwalk, CT)|
|Filing Date:||Feb 06, 1976|
|Claims:||1. A compound selected from the group consisting of spiro (1,3-dioxolane-4,3') quinuclidines of the formula ##STR3## wherein R.sub.1 and R.sub.2 are each selected from the group consisting of hydrogen, lower alkyl, and phenyl, and physiologically compatible salts thereof. |
2. A compound according to claim 1, wherein R.sub.1 is hydrogen and R.sub.2 is methyl; 2-methyl spiro (1,3-dioxolane-4,3') quinuclidine, in the form of in the form of the cis isomer or trans isomer or mixtures thereof.
3. A compound according to claim 1, wherein R.sub.1 and R.sub.2 are methyl: 2,2-dimethyl spiro (1,3-dioxolane-4,3') quinuclidine.
4. A compound according to claim 1, wherein R.sub.1 and R.sub.2 are phenyl: 2,2-diphenyl spiro (1,3-dioxolane-4,3') quinuclidine.
5. A pharmaceutical composition for treatment to effect cholinergic stimulation, or for the treatment of manifestations of glaucoma, or for the treatment of myestenia gravis, which comprises a corresponding treatment effective amount of the compound of claim 2 and a suitable carrier.
6. The pharmaceutical composition of claim 5 for effecting cholinergic stimulation wherein the active ingredient is the cis-isomer of 2-methyl spiro (1,3-dioxolane-4,3') quinuclidine, or a salt thereof.
7. A pharmaceutical composition for treatment to induce sustained mydriasis, or for the treatment of disorders characterized by an excess of central or peripheral acetycholine-like activity, of intoxication by organo-phosphorus compounds or by carbamates, or for the treatment for conditions where central dopaminergic activity is pathologically reduced, which comprises a corresponding treatment effective amount of the compound of claim 4 or a salt thereof and a suitable carrier.
8. A process for treating disorders due to a deficiency of acetylcholine in the central nervous system which comprises administering an acetylcholine deficiency treating effective amount of the compound of claim 2.
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