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Details for Patent: 4,104,397

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Details for Patent: 4,104,397

Title: Spiro (1,3-dioxolane-4,3') quinuclidine compounds
Abstract:Novel spiro (1,3-dioxolane-4,3') quinuclidine compounds of the formula ##STR1## wherein R.sub.1 and R.sub.2, which may be identical or different, each designates a member of the group hydrogen, alkyl or aryl; a process for the production of these and pharmaceutical compositions of matter containing such compound as active ingredient.
Inventor(s): Cohen; Sasson (Tel-Aviv, IL), Fisher; Abraham (Holon, IL)
Assignee: The Purdue Frederick Company (Norwalk, CT)
Filing Date:Feb 06, 1976
Application Number:05/656,056
Claims:1. A compound selected from the group consisting of spiro (1,3-dioxolane-4,3') quinuclidines of the formula ##STR3## wherein R.sub.1 and R.sub.2 are each selected from the group consisting of hydrogen, lower alkyl, and phenyl, and physiologically compatible salts thereof.

2. A compound according to claim 1, wherein R.sub.1 is hydrogen and R.sub.2 is methyl; 2-methyl spiro (1,3-dioxolane-4,3') quinuclidine, in the form of in the form of the cis isomer or trans isomer or mixtures thereof.

3. A compound according to claim 1, wherein R.sub.1 and R.sub.2 are methyl: 2,2-dimethyl spiro (1,3-dioxolane-4,3') quinuclidine.

4. A compound according to claim 1, wherein R.sub.1 and R.sub.2 are phenyl: 2,2-diphenyl spiro (1,3-dioxolane-4,3') quinuclidine.

5. A pharmaceutical composition for treatment to effect cholinergic stimulation, or for the treatment of manifestations of glaucoma, or for the treatment of myestenia gravis, which comprises a corresponding treatment effective amount of the compound of claim 2 and a suitable carrier.

6. The pharmaceutical composition of claim 5 for effecting cholinergic stimulation wherein the active ingredient is the cis-isomer of 2-methyl spiro (1,3-dioxolane-4,3') quinuclidine, or a salt thereof.

7. A pharmaceutical composition for treatment to induce sustained mydriasis, or for the treatment of disorders characterized by an excess of central or peripheral acetycholine-like activity, of intoxication by organo-phosphorus compounds or by carbamates, or for the treatment for conditions where central dopaminergic activity is pathologically reduced, which comprises a corresponding treatment effective amount of the compound of claim 4 or a salt thereof and a suitable carrier.

8. A process for treating disorders due to a deficiency of acetylcholine in the central nervous system which comprises administering an acetylcholine deficiency treating effective amount of the compound of claim 2.
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