Generated: May 29, 2017
|Abstract:||The present invention relates to pyridine derivatives having the formula: ##STR1## in which: R is a radical selected from a phenyl radical mono- and polysubstituted with a group selected from the aryl, carboxy, alkoxycarbonyl, cyano, hydroxymethyl and ethylenedioxy groups; a styryl, thienyl and benzhydryl radical optionally mono- and polysubstituted with a group selected from halogen, lower alkyl, lower alkoxy, aryl, nitro, amino, sulfonylamino, carboxy, alkoxycarbonyl, cyano, hydroxymethyl and methylenedioxy; R.sub.1 and R.sub.2 represent each a group selected from hydrogen, halogen, hydroxy, lower alkyl, lower alkoxy, nitro and amino; R.sub.3 represents a group selected from hydrogen, halogen, hydroxy, lower alkyl, lower alkoxy, nitro and amino; and n is an integer from 1 to 15, And in which the symbols R.sub.3 may have different meanings in each radical CHR.sub.3 when n is greater than 1, And their inorganic and organic acid addition salts and quaternary ammonium derivatives, particularly 5-o-cyanobenzyl-4,5,6,7-tetrahydro-thieno[3,2-c]pyridine maleate. Said derivatives are therapeutically valuable in view of their anti-inflammatory and vasodilator activities and their inhibitor action on blood-platelet aggregation.|
|Inventor(s):||Amselem; Armand (Toulouse, FR)|
|Assignee:||Centre d'Etudes Pour L'Industrie Pharmaceutique (Toulouse, FR)|
|Filing Date:||Jul 09, 1976|
|Claims:||1. 5-o-cyanobenzyl-4,5,6,7-tetrahydrothieno[3,2-c]pyridine maleate.|
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