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Details for Patent: 4,083,985

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Details for Patent: 4,083,985

Title: 6-Oxa-1-aza tricyclo dodecan-5-ones as psychomotor stimulators
Abstract:Compounds of the general formula ##STR1## wherein X is selected from the group consisting of oxygen CH.sub.2 and CH radicals, and when X designates oxygen, R designates alkyl, isoalkyl, aralkyl, and substituted aryl groups and when X designates ##STR2## then R designates alkyl, phenyl or substituted phenyl group, and A--B is a single bond and when X designates >CH, and A--B is a double bond, R designates alkyl, phenyl or substituted phenyl groups and physiologically acceptable salts of these, and pharmaceutical compositions containing same as active ingredient.
Inventor(s): Cohen; Sasson (Tel-Aviv, IL), Fisher; Abraham (Holon, IL)
Assignee: The Purdue Frederick Company (New York, NY)
Filing Date:Feb 06, 1976
Application Number:05/655,650
Claims:1. A compound selected from the group consisting of compounds of the formula: ##STR9## wherein R is selected from the group consisting of hydrogen, lower alkyl, cyclopentyl, cyclohexyl, thienyl, phenyl, methylphenyl, methoxyphenyl, chlorophenyl, trifuloromethylphenyl, aminophenyl, di-loweralkylamino phenyl and benzyl, and physiologically acceptable salts thereof.

2. 4-Methyl-6-oxa-1-azatricyclo (6.2.2.0.sup.2,7) dodecan-5-one and its hydrochloride salt.

3. A compound of claim 1, 4-phenyl-6-oxa-1-azatricyclo(6.2.2.0.sup.2,7)dodecan-5-one and its salts.

4. A compound of claim 1, 6-oxa-1-azatricyclo (6.2.2.0.sup.2,7) dodecan-5-one and its salts.

5. A compound of claim 1, 4-methyl-6-oxa-1-azatricyclo (6.2.2.0.sup.2,7) dodecan-5-one and its salts.

6. A compound of claim 1, 4-ethyl-6-oxa-1-tricyclo (6.2.2.0.sup.2,7) dodecan-5-one and its salts.

7. A compound of claim 1, 4-isopropyl-6-oxa-1-azatricyclo (6.2.2.0.sup.2,7) dodecan-5-one and its salts.

8. A compound of claim 1, 4-n-butyl-6-oxa-1-azatricyclo (6.2.2.0.sup.2,7) dodecan5-one and its salts.

9. A compound of claim 1, 4-benzyl-6-oxa-1-azatricyclo (6.2.2.0.sup.2,7) dodecan-5-one and its salts.

10. A compound of claim 1, 4-p-methylphenyl-6-oxa-1-azatricyclo (6.2.2.0.sup.2,7) dodecan-5-one and its salts.

11. A compound of claim 1, 4-p-chlorophenyl-6-oxa-1-azatricyclo (6.2.2.0.sup.2,7) dodecan-5-one and salts thereof.

12. A compound of claim 1, 4-m-methoxyphenyl-6-oxa-1-azatricyclo (6.2.2.0.sup.2,7) dodecan-5-one and its salts.

13. A pharmaceutical preparation for psychomotor stimulation comprising a therapeutically sufficient quantity of a compound of claim 1 and a pharmaceutically acceptable carrier therefor.

14. A pharmaceutical preparation for psychomotor stimulation comprising from 10 mg. to 100 mg. of a compound of claim 1 per unit dose and a pharmaceutically acceptable carrier therefor.

15. A pharmaceutical mydriatic solution comprising a therapeutically sufficient quantity of the compound of claim 1 dissolved in an essentially aqueous solvent.
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