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|Abstract:||Pyridinium derivatives having the formula: ##STR1## in which X is O or S; R is benzoyl optionally substituted with at least halogen or lower alkyl, lower alkoxy, hydroxy or nitro; R.sub.1 is hydrogen, halogen, hydroxy or lower alkyl, R.sub.2 is hydrogen or halogen and n is from 1 to 2, and in which R.sub.1 may be different in each CHR.sub.1 when n is 2. Said derivatives are therapeutically useful for their anti-arrhythmic activity.|
|Inventor(s):||Castaigne; Albert Rene Joseph (Toulouse, FR)|
|Assignee:||Centre d'Etudes Pour l'Industrie Pharmaceutique (Toulouse, FR)|
|Filing Date:||Aug 18, 1976|
|Claims:||1. A compound selected from the group consisting of 5-phenacyl-thieno[3,2-c]pyridinium bromide, 5-(o-methoxy-phenacyl)-thieno[3,2-c]pyridinium bromide, 2-chloro-5-phenacyl-thieno[3,2-c]pyridinium bromide, N-parachlorophenacyl-thieno[3,2-c]pyridinium bromide, 5-(3,4-dihydroxyphenacyl)-thieno[3,2-c]pyridinium chloride, 5-para-fluorophenacyl-thieno[3,2-c]pyridinium chloride, N-(para-hydroxyphenacyl)-thieno[3,2-c]pyridinium chloride, N-(para-methoxyphenacyl)-thieno[3,2-c]pyridinium bromide and N-(meta-methoxyphenacyl)-thieno[3,2-c]pyridinium bromide. |
2. 5-phenacyl-thieno[3,2-c]pyridinium bromide.
3. 5-(o-methoxy-phenacyl)-thieno[3,2-c]pyridinium bromide.
4. 2-chloro-5-phenacyl-thieno[3,2-c]pyridinium bromide.
5. N-parachloro-phenacyl-thieno[3,2-c]pyridinium bromide.
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