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Generated: January 21, 2018

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Title: Thieno-pyridine derivatives
Abstract:Pyridinium derivatives having the formula: ##STR1## in which X is O or S; R is benzoyl optionally substituted with at least halogen or lower alkyl, lower alkoxy, hydroxy or nitro; R.sub.1 is hydrogen, halogen, hydroxy or lower alkyl, R.sub.2 is hydrogen or halogen and n is from 1 to 2, and in which R.sub.1 may be different in each CHR.sub.1 when n is 2. Said derivatives are therapeutically useful for their anti-arrhythmic activity.
Inventor(s): Castaigne; Albert Rene Joseph (Toulouse, FR)
Assignee: Centre d'Etudes Pour l'Industrie Pharmaceutique (Toulouse, FR)
Filing Date:Aug 18, 1976
Application Number:05/715,579
Claims:1. A compound selected from the group consisting of 5-phenacyl-thieno[3,2-c]pyridinium bromide, 5-(o-methoxy-phenacyl)-thieno[3,2-c]pyridinium bromide, 2-chloro-5-phenacyl-thieno[3,2-c]pyridinium bromide, N-parachlorophenacyl-thieno[3,2-c]pyridinium bromide, 5-(3,4-dihydroxyphenacyl)-thieno[3,2-c]pyridinium chloride, 5-para-fluorophenacyl-thieno[3,2-c]pyridinium chloride, N-(para-hydroxyphenacyl)-thieno[3,2-c]pyridinium chloride, N-(para-methoxyphenacyl)-thieno[3,2-c]pyridinium bromide and N-(meta-methoxyphenacyl)-thieno[3,2-c]pyridinium bromide.

2. 5-phenacyl-thieno[3,2-c]pyridinium bromide.

3. 5-(o-methoxy-phenacyl)-thieno[3,2-c]pyridinium bromide.

4. 2-chloro-5-phenacyl-thieno[3,2-c]pyridinium bromide.

5. N-parachloro-phenacyl-thieno[3,2-c]pyridinium bromide.
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