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Details for Patent: 4,070,371

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Details for Patent: 4,070,371

Title: Derivatives of 1,3,4,9-tetrahydropyrano[3,4-b]indole-1-acetic acid
Abstract:Indole derivatives characterized by having a 1,3,4,9-tetrahydropyrano[3,4-b]indole or 1,3,4,9-tetrahydrothiopyrano[3,4-b]indole nucleus bearing a substituent in position 1, said substituent incorporating an acid, ester or amide function therein, are disclosed. The nucleus is further substituted at position 1 and may be optionally substituted at positions 3, 4, 5, 6, 7, 8, and 9. The derivatives are useful antiinflammatory, analgesic, antibacterial and antifungal agents and methods for their preparation and use are also disclosed.
Inventor(s): Demerson; Christopher A. (Montreal, CA), Humber; Leslie G. (Dollard des Ormeaux, CA), Dobson; Thomas A. (Dollard des Ormeaux, CA), Jirkovsky; Ivo L. (Montreal, CA)
Assignee: American Home Products Corporation (New York, NY)
Filing Date:Dec 13, 1976
Application Number:05/749,631
Claims:1. 1-Cyclopropyl-1,3,4,9-tetrahydropyrano[3,4-b]indole-1-acetic acid.

2. 1-Benzyl-1,3,4,9-tetrahydropyrano[3,4-b]indole-1-acetic acid.

3. 1-Ethyl-6-fluoro-1,3,4,9-tetrahydropyrano[3,4-b]indole-1-acetic acid.

4. 7-Chloro-1-ethyl-4-methyl-1,3,4,9-tetrahydropyrano[3,4-b]indole-1-acetic acid.

5. 1-Ethyl-7-fluoro-1,3,4,9-tetrahydropyrano[3,4-b]indole-1-acetic acid.

6. 8-Chloro-1-ethyl-4-methyl-1,3,4,9-tetrahydropyrano[3,4-b]indole-1-acetic acid.

7. 1,8-Diethyl-4-methyl-1,3,4,9-tetrahydropyrano[3,4-b]indole-1-acetic acid.

8. 1-Ethyl-8-propyl-1,3,4,9-tetrahydropyrano[3,4-b]indole-1-actic acid.

9. 1-Ethyl-8-isopropyl-1,3,4,9-tetrahydropyrano[3,4-b]indole1-acetic acid.

10. 8-Butyl-1-ethyl-1,3,4,9-tetrahydropyrano[3,4-b]indole-1-acetic acid.

11. 8-sec-Butyl-1-ethyl-1,3,4,9-tetrahydropyrano[3,4-b]indole-1-acetic acid.

12. 1-Ethyl-8-isobutyl-1,3,4,9-tetrahydropyrano[3,4-b]indole-1-acetic acid.

13. 8-tert-Butyl-1-ethyl-1,3,4,9-tetrahydropyrano[3,4-b]indole-1-acetic acid.

14. 1-Ethyl-4,5,8-trimethyl-1,3,4,9-tetrahydropyrano[3,4-b]indole-1-acetic acid.

15. 7,8-Dichloro-1-ethyl-1,3,4,9-tetrahydropyrano[3,4-b]indole-1-acetic acid.

16. 8- Chloro-1-ethyl-7-methyl-1,3,4,9-tetrahydropyrano[3,4-b]indole-1-acetic acid

17. 7-Chloro-1-ethyl-8-methyl-1,3,4,9-tetrahydropyrano[3,4-b]indole-1-aceti c acid.

18. 1-E thyl-7-fluoro-8-methyl-1,3,4,9-tetrahydropyrano[3,4-b]indole-1-acetic acid.

19. 8-Ethyl-1-propyl-1,3,4,9-tetrahydropyrano[3,4-b]indole-1-acetic acid.

20. 1,8-Dipropyl-1,3,4,9-tetrahydropyrano[3,4-b]indole-1-acetic acid.

21. 7-Chloro-8-methyl-1-propyl-1,3,4,9-tetrahydropyrano[3,4-b]indole- 1-acetic acid.
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