.

Pharmaceutical Business Intelligence

  • Anticipate P&T budget requirements
  • Evaluate market entry opportunities
  • Find generic sources and suppliers
  • Predict branded drug patent expiration

► Plans and Pricing

Upgrade to enjoy subscriber-only features like email alerts and data export. See the Plans and Pricing

DrugPatentWatch Database Preview

Details for Patent: 4,069,307

« Back to Dashboard

Details for Patent: 4,069,307

Title: Drug-delivery device comprising certain polymeric materials for controlled release of drug
Abstract:Drug-delivery device for releasing a drug at a continuous and controlled rate for a prolonged period of time is comprised of a shaped body of polymeric material containing a pharmaceutically acceptable drug and permeable to passage of the drug by diffusion. The polymeric material is an ethylene-vinyl acetate copolymer having a vinyl acetate content of about 4 to 80% by weight and a melt index of about 0.1 to 1000 grams per 10 minutes.
Inventor(s): Higuchi; Takeru (Lawrence, KS), Hussain; Anwar (Lawrence, KS)
Assignee: Alza Corporation (Palo Alto, CA)
Filing Date:May 30, 1975
Application Number:05/582,353
Claims:1. A shape retaining implant for releasing drug formed of a copolymer compatible with body tissue, the improvement wherein the implant is formed of a matrix of ethylene-vinyl acetate copolymer containing drug, said drug mixed throughout the copolymer which has a vinyl acetate content of 4 to 80% by weight, a melt index of about 0.1 to 1000 grams per ten minutes, is permeable to the passage of the drug by diffusion, and capable of releasing a therapeutically effective amount of drug to body tissue at a predetermined and controlled rate over a prolonged period of time.

2. The implant of claim 1, wherein said ethylene-vinyl acetate copolymer has a vinyl acetate content of about 4 to 50% by weight and a melt index of about 0.5 to 100 grams per 10 minutes.

3. The implant of claim 1, wherein said ethylene-vinyl acetate copolymer has a vinyl acetate content of about 4 to 40% by weight and a melt index of about 0.15 to 25 grams per 10 minutes.

4. The implant of claim 1, wherein the ethylene-vinyl acetate copolymer has a vinyl acetate content of 4 to 50% and a frequency of acetoxy groups on the polyethylene backbone of 1/150 to 1.8.

5. The implant of claim 1, wherein the ethylene-vinyl acetate copolymer has a density of about 0.920 to 0.980 and a vinyl acetate content of 4 to 50%.

6. The implant of claim 1, wherein the copolymer contains from about 250 nanograms to 5 grams of drug capable of diffusion through said polymeric material in a therapeutically effective amount over a prolonged period of time.

7. The implant of claim 1, wherein the copolymer is a cylinder shaped body.

8. The implant of claim 1, wherein the copolymer contains diethylstilbestrol that is released in a therapeutically effective amount over a prolonged period of time.

9. A method for administering a pharmaceutically acceptable drug to an animal which method comprises placing an implant shaped, sized and adapted for placement in the animal and formed of a non-toxic copolymer material, the improvement wherein the implant is a matrix of ethylene-vinyl acetate copolymer containing a dosage unit amount of drug selected from the group consisting of locally acting and systemically acting drugs mixed therethrough and capable of dissolving in and diffusing through the copolymer at a controlled rate over a prolonged period of time, said copolymer having a vinyl acetate content of 4 to 80% by weight, a melt index of 0.1 to 1000 grams per 10 minutes and permeable to the passage of drug which drug passes through the ethylene-vinyl acetate copolymer in a therapeutically effective amount to produce the local or systemic action in the animal.
« Back to Dashboard

For more information try a trial or see the database preview and plans and pricing

Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verifification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.

`abc