.

Pharmaceutical Business Intelligence

  • Anticipate P&T budget requirements
  • Evaluate market entry opportunities
  • Find generic sources and suppliers
  • Predict branded drug patent expiration

► Plans and Pricing

Upgrade to enjoy subscriber-only features like email alerts and data export. See the Plans and Pricing

DrugPatentWatch Database Preview

Details for Patent: 4,064,132

« Back to Dashboard

Details for Patent: 4,064,132

Title: Aroyl-substituted phenylacetamide derivatives
Abstract:Compounds of the class of aroyl-substituted phenylacetic acids and corresponding esters, amides and hydroxamic acids, useful as anti-inflammatory agents and certain novel precursors therefor.
Inventor(s): Janssen; Paul Adriaan Jan (Vosselaar (Turnhout), BE), Van Daele; Georges Henri Paul (Turnhout, BE), Boey; Jozef Martin (Wilrijk (Antwerp), BE)
Assignee: Janssen Pharmaceutica N.V. (Beerse, BE)
Filing Date:Dec 10, 1976
Application Number:05/749,575
Claims:1. An aroyl substituted .alpha.-R.sub.2 -.alpha.-R.sub.3 -phenylacetic acid derivative having the formula: ##STR32## wherein: ArCO is an aroyl substituent the Ar function of which is a member selected from the group consisting of 2-thienyl, 5-loweralkyl-2-thienyl, 5-halo-2-thienyl, 2-naphthyl and 3-pyridyl, said ArCO being in the meta- or para-position relative to the acetic acid function;

either of R and R.sub.1 is hydrogen, the other being a member selected from the group consisting of hydrogen, halo and loweralkyl, provided that, when said R is halo or loweralkyl, then said ArCO is in the aforementioned paraposition, and when said R.sub.1 is halo or loweralkyl, then said ArCO is in the aforementioned meta-position, and further provided that when said R or R.sub.1 is halo, then said Ar is a member selected from the group consisting of 2-thienyl, 5-loweralkyl-2-thienyl and 5-halo-2-thienyl;

either of R.sub.2 and R.sub.3 is a member selected from the group consisting of hydrogen, allyl and loweralkyl, the other being a member selected from the group consisting of hydrogen and loweralkyl, provided that, when either of said R.sub.2 and R.sub.3 is allyl, the other is hydrogen, and when either of said R.sub.2 and R.sub.3 is loweralkyl, the other is a member selected from the group consisting of hydrogen and loweralkyl;

R.sub.2 and R.sub.3 taken together, is an alkylene bridge attached to the .alpha.-carbon of the acetic acid function: ##STR33## wherein n is an integer from 2 to 5; and Y is a member selected from the group consisting of amino, anilino, halo-substituted anilino, loweralkylanilino, loweralkyloxyanilino, piperidino, hydroxyethylamino, and hydroxyamino.

2. An aroyl substituted .alpha.-R.sub.2 -.alpha.-R.sub.3 -phenylacetic acid derivative having the formula: ##STR34## wherein ArCO is an aroyl substituent the Ar function of which is a member selected from the group consisting of 2-thienyl, 5-methyl-2-thienyl, 5-chloro-2-thienyl, 2-naphthyl and 3-pyridyl, said ArCO being in the meta- or para-position relative to the acetic acid function;

either of R and R.sub.1 is hydrogen, the other being a member selected from the group consisting of hydrogen, chloro and methyl, provided that when said R is chloro or methyl, then said ArCO is in the forementioned para-position, and when said R.sub.1 is chloro or methyl, then said Ar-CO is in the aforementioned meta-position, and further provided that, when said R or R.sub.1 is chloro, then said Ar is a member selected from the group consisting of 2-thienyl, 5-methyl-2-thienyl and 5-chloro-2-thienyl;

either of R.sub.2 and R.sub.3 is a member selected from the group consisting of hydrogen, allyl and loweralkyl, the other being a member selected from the group consisting of hydrogen and loweralkyl, provided that, when either of said R.sub.2 and R.sub.3 is allyl, the other is hydrogen, and when either of said R.sub.2 and R.sub.3 is loweralkyl, the other is a member selected from the group consisting of hydrogen and loweralkyl;

R.sub.2 and R.sub.3, taken together, is an alkylene bridge attached to the .alpha.-carbon of the acetic acid function: ##STR35## wherein n is an integer from 2 to 5; and Y is a member selected from the group consisting of amino, anilino, halosubstituted anilino, preferably chloro-anilino, loweralkyl-anilino, such as methylanilino; loweralkyloxyanilino, preferably methoxyanilino; piperidino, hydroxyethylamino, and hydroxylamino.
« Back to Dashboard

For more information try a trial or see the database preview and plans and pricing

How are People Using DrugPatentWatch?

Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verifification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.

`abc