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Details for Patent: 4,060,640

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Details for Patent: 4,060,640

Title: Therapeutic agents
Abstract:O-HALOBENZYLIDENEAMINOGUANIDINES ARE EMPLOYED AS CENTRAL NERVOUS SYSTEM DEPRESSANTS, AS CARDIOVASCULAR DEPRESSANTS, AND/OR AS ANTIDEPRESSANTS FOR OVERCOMING PSYCHIC DEPRESSION.
Inventor(s): Kodama; Jiro K. (Herne Bay, EN), Haynes; George R. (Modesto, CA), Albert; James R. (Modesto, CA)
Assignee: Shell Oil Company (Houston, TX)
Filing Date:Jun 08, 1976
Application Number:05/693,998
Claims:1. A method of inducing a central nervous system depressant response in mammals to reduce hyperexcitability and induce sedation which comprises administering to a mammal an effective dosage for inducing a central nervous system depressant response of a compound of the formula ##STR4## wherein X is halogen or trifluoromethyl, Y and Z may be the same or different and each is hydrogen, halogen, trifluoromethyl or alkyl of 1 to 4 carbon atoms, R, R', R" and R.degree. each is hydrogen, alkyl of 1 to 4 carbon atoms, alkenyl of 2 to 4 carbon atoms or alkynyl of 2 to 4 carbon atoms with the proviso that R" and R.degree. may together form an ethylene or vinylene bridge, with the further proviso that one of Y and R must be hydrogen, or a pharmaceutically acceptable salt thereof.

2. A method according to claim 1 wherein X and Y each is chlorine, and Z, R, R', R" and R.degree. each is hydrogen, and the salt is a hydrochloric acid salt.

3. A method according to claim 1 wherein X and Y each is chlorine, and Z, R, R', R" and R.degree. each is hydrogen.

4. A method according to claim 1 wherein X and Y each is middle halogen and Z, R, R', R" and R.degree. each is hydrogen, and the salt is a hydrohalic acid salt.
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