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|Abstract:||O-HALOBENZYLIDENEAMINOGUANIDINES ARE EMPLOYED AS CENTRAL NERVOUS SYSTEM DEPRESSANTS, AS CARDIOVASCULAR DEPRESSANTS, AND/OR AS ANTIDEPRESSANTS FOR OVERCOMING PSYCHIC DEPRESSION.|
|Inventor(s):||Kodama; Jiro K. (Herne Bay, EN), Haynes; George R. (Modesto, CA), Albert; James R. (Modesto, CA)|
|Assignee:||Shell Oil Company (Houston, TX)|
|Filing Date:||Jun 08, 1976|
|Claims:||1. A method of inducing a central nervous system depressant response in mammals to reduce hyperexcitability and induce sedation which comprises administering to a mammal an effective dosage for inducing a central nervous system depressant response of a compound of the formula ##STR4## wherein X is halogen or trifluoromethyl, Y and Z may be the same or different and each is hydrogen, halogen, trifluoromethyl or alkyl of 1 to 4 carbon atoms, R, R', R" and R.degree. each is hydrogen, alkyl of 1 to 4 carbon atoms, alkenyl of 2 to 4 carbon atoms or alkynyl of 2 to 4 carbon atoms with the proviso that R" and R.degree. may together form an ethylene or vinylene bridge, with the further proviso that one of Y and R must be hydrogen, or a pharmaceutically acceptable salt thereof. |
2. A method according to claim 1 wherein X and Y each is chlorine, and Z, R, R', R" and R.degree. each is hydrogen, and the salt is a hydrochloric acid salt.
3. A method according to claim 1 wherein X and Y each is chlorine, and Z, R, R', R" and R.degree. each is hydrogen.
4. A method according to claim 1 wherein X and Y each is middle halogen and Z, R, R', R" and R.degree. each is hydrogen, and the salt is a hydrohalic acid salt.