Generated: April 26, 2017
|Title:||Aroyl-substituted phenylmalonic acid derivatives|
|Abstract:||Compounds of the class of aroyl-substituted phenylacetic acids and corresponding esters, amides and hydroxamic acids, useful as anti-inflammatory agents and certain novel precursors therefor.|
|Inventor(s):||Janssen; Paul Adriaan Jan (Vosselaar (Turnhout), BE), Van Daele; Georges Henri Paul (Turnhout, BE), Boey; Jozef Martin (Wilrijk (Antwerp), BE)|
|Assignee:||Janssen Pharmaceutica N.V. (Beerse, BE)|
|Filing Date:||Dec 10, 1976|
|Claims:||1. A diloweralkyl malonate having the formula: ##STR32## wherein: ArCO is an aroyl substituent the Ar function of which is a member selected from the group consisting of 2-thienyl, 5-methyl-2-thienyl, 5-chloro-2-thienyl, 2-naphthyl and 3-pyridyl; |
R is a member selected from the group consisting of hydrogen, loweralkyl and halo, provided that when said R is halo, then said Ar is 2-thienyl-5-methyl-2-thienyl or 5-chloro2-thienyl;
R.sub.2 is a member selected from the group consisting of hydrogen, allyl and loweralkyl.
2. Diethyl 2-methyl-2-[p-(2-thenoyl)phenyl]malonate.
3. Diethyl 2-[3-chloro-4-(2-thenoyl)phenyl]-2-methylmalonate.
4. Diethyl 2-methyl-2-[p-(3-pyridylcarbonyl)phenyl]-malonate.
5. Diethyl 2-methyl-2-[p-(5-methyl-2-thenoyl)phenyl]-malonate.
6. Diethyl 2-methyl-2-[p-(2-naphthoyl)phenyl]malonate.
7. Diethyl 2-ethyl-2-[p-(2thenoyl)phenyl]malonate.
8. Diethyl 2-allyl-2-[p-(2-thenoyl)phenyl]malonate.
9. Diethyl 2-methyl-2-[p-(2-thenoyl)-m-tolyl]malonate.
Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verifification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.