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|Title:||Aroyl-substituted phenylmalonic acid derivatives|
|Abstract:||Compounds of the class of aroyl-substituted phenylacetic acids and corresponding esters, amides and hydroxamic acids, useful as anti-inflammatory agents and certain novel precursors therefor.|
|Inventor(s):||Janssen; Paul Adriaan Jan (Vosselaar (Turnhout), BE), Van Daele; Georges Henri Paul (Turnhout, BE), Boey; Jozef Martin (Wilrijk (Antwerp), BE)|
|Assignee:||Janssen Pharmaceutica N.V. (Beerse, BE)|
|Filing Date:||Dec 10, 1976|
|Claims:||1. A diloweralkyl malonate having the formula: ##STR32## wherein: ArCO is an aroyl substituent the Ar function of which is a member selected from the group consisting of 2-thienyl, 5-methyl-2-thienyl, 5-chloro-2-thienyl, 2-naphthyl and 3-pyridyl; |
R is a member selected from the group consisting of hydrogen, loweralkyl and halo, provided that when said R is halo, then said Ar is 2-thienyl-5-methyl-2-thienyl or 5-chloro2-thienyl;
R.sub.2 is a member selected from the group consisting of hydrogen, allyl and loweralkyl.
2. Diethyl 2-methyl-2-[p-(2-thenoyl)phenyl]malonate.
3. Diethyl 2-[3-chloro-4-(2-thenoyl)phenyl]-2-methylmalonate.
4. Diethyl 2-methyl-2-[p-(3-pyridylcarbonyl)phenyl]-malonate.
5. Diethyl 2-methyl-2-[p-(5-methyl-2-thenoyl)phenyl]-malonate.
6. Diethyl 2-methyl-2-[p-(2-naphthoyl)phenyl]malonate.
7. Diethyl 2-ethyl-2-[p-(2thenoyl)phenyl]malonate.
8. Diethyl 2-allyl-2-[p-(2-thenoyl)phenyl]malonate.
9. Diethyl 2-methyl-2-[p-(2-thenoyl)-m-tolyl]malonate.