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Generated: August 17, 2017

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Title: Aroyl-substituted phenylmalonic acid derivatives
Abstract:Compounds of the class of aroyl-substituted phenylacetic acids and corresponding esters, amides and hydroxamic acids, useful as anti-inflammatory agents and certain novel precursors therefor.
Inventor(s): Janssen; Paul Adriaan Jan (Vosselaar (Turnhout), BE), Van Daele; Georges Henri Paul (Turnhout, BE), Boey; Jozef Martin (Wilrijk (Antwerp), BE)
Assignee: Janssen Pharmaceutica N.V. (Beerse, BE)
Filing Date:Dec 10, 1976
Application Number:05/749,574
Claims:1. A diloweralkyl malonate having the formula: ##STR32## wherein: ArCO is an aroyl substituent the Ar function of which is a member selected from the group consisting of 2-thienyl, 5-methyl-2-thienyl, 5-chloro-2-thienyl, 2-naphthyl and 3-pyridyl;

R is a member selected from the group consisting of hydrogen, loweralkyl and halo, provided that when said R is halo, then said Ar is 2-thienyl-5-methyl-2-thienyl or 5-chloro2-thienyl;

R.sub.2 is a member selected from the group consisting of hydrogen, allyl and loweralkyl.

2. Diethyl 2-methyl-2-[p-(2-thenoyl)phenyl]malonate.

3. Diethyl 2-[3-chloro-4-(2-thenoyl)phenyl]-2-methylmalonate.

4. Diethyl 2-methyl-2-[p-(3-pyridylcarbonyl)phenyl]-malonate.

5. Diethyl 2-methyl-2-[p-(5-methyl-2-thenoyl)phenyl]-malonate.

6. Diethyl 2-methyl-2-[p-(2-naphthoyl)phenyl]malonate.

7. Diethyl 2-ethyl-2-[p-(2thenoyl)phenyl]malonate.

8. Diethyl 2-allyl-2-[p-(2-thenoyl)phenyl]malonate.

9. Diethyl 2-methyl-2-[p-(2-thenoyl)-m-tolyl]malonate.
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