Deep knowledge on
small-molecule drugs and
the 110,000 global patents
Proactively manage your pharmacy inventory
Anticipate generic drug launch
Drug patents …
… from Kazakhstan to Kalamazoo
Manage your formulary budget
Find generic entry opportunities
Flat-rate pricing for predictable budgeting
Short-term plans for project- or client-based billing
Upgrade to enjoy subscriber-only features like email alerts and data export. See the Plans and Pricing
|Title:||Certain 4-phenoxy(or phenylthio)-3-n-acylated-sulfonamido-pyridines|
|Abstract:||This invention relates to new derivatives of pyridine having hypo-uricemic or hypolipemic properties. The new derivatives of pyridine may be represented by the following general formula: ##STR1## in which X represents an oxy or thio group, R.sub.1 represents hydrogen, a group of the formula R.sub.3 NHCO (II), wherein R.sub.3 represents a C.sub.1 -C.sub.4 -alkyl, cycloalkyl or possibly substituted phenyl group, or a group of the formula R.sub.4 --CO (III) in which R.sub.4 represents a C.sub.1- C.sub.4 -alkyl group or a possibly substituted phenyl group, and R', R" and R'" represent each a possible substituent selected from the group comprising the halogens, the trifluoromethyl and the C.sub.1- C.sub.4 alkyl groups.|
|Inventor(s):||Delarge; Jacques E. (Dolembreux, BE), Lapiere; Charles L. (Tongeren, BE), Georges; Andre H. (Ottignies, BE)|
|Assignee:||A. Christiaens Societe Anonyme (Brussels, BE)|
|Filing Date:||Jun 09, 1976|
|Claims:||1. A compound of the following structure: ##STR8## in which X represents an oxy or thio group; R.sub.1 represetns a group of the formula: ##STR9## wherein R.sub.3 represents a C.sub.1 -C.sub.4 -alkyl, cyclohexyl, unsubstituted phenyl or substituted phenyl group, or R.sub.1 represents a group of the formula: |
wherein R.sub.4 represents a C.sub.1 -C.sub.4 -alkyl group or an unsubstituted or substituted phenyl group; R', R" and R'" represent each hydrogen or a substituent selected from the group comprising the halogen atoms, the trifluoromethyl group and the C.sub.1 -C.sub.4 -alkyl groups, as well as the pyridine N-oxide of the compounds of Formula I and the pharmaceutically acceptable base and acid addition salts of said compounds.
2. A compound according to claim 1, in which X is a thio group, R.sub.1 is acetyl, propionyl, parachlorobenzoyl or a R.sub.3 -carbamyl group, and one of the symbols R', R" and R'" represent 3-methyl or one or two of the symbols R', R", and R'" represent chlorine, the other being hydrogen.
3. A compound according to claim 1, in which X is a thio group, R.sub.1 is acetyl, propionyl, para-chlorobenzoyl or a R.sub.3 -carbamyl group, and one of the symbols R', R" and R'" represent 3-trifluoromethyl or 4-methyl, the others being hydrogen.
4. 4-(3'-chlorophenoxy)-3-R.sub.3 -carbamylsulfonamidopyridines according to claim 1.
6. Pharmaceutical compositions containing a hypo-uricemic or hypo-lipemic effective amount of at least one compound according to claim 1 as active ingredient, together with a pharmaceutical carrier or vehicle.
Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verifification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.