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Details for Patent: 4,055,650

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Details for Patent: 4,055,650

Title: Certain 4-phenoxy(or phenylthio)-3-n-acylated-sulfonamido-pyridines
Abstract:This invention relates to new derivatives of pyridine having hypo-uricemic or hypolipemic properties. The new derivatives of pyridine may be represented by the following general formula: ##STR1## in which X represents an oxy or thio group, R.sub.1 represents hydrogen, a group of the formula R.sub.3 NHCO (II), wherein R.sub.3 represents a C.sub.1 -C.sub.4 -alkyl, cycloalkyl or possibly substituted phenyl group, or a group of the formula R.sub.4 --CO (III) in which R.sub.4 represents a C.sub.1- C.sub.4 -alkyl group or a possibly substituted phenyl group, and R', R" and R'" represent each a possible substituent selected from the group comprising the halogens, the trifluoromethyl and the C.sub.1- C.sub.4 alkyl groups.
Inventor(s): Delarge; Jacques E. (Dolembreux, BE), Lapiere; Charles L. (Tongeren, BE), Georges; Andre H. (Ottignies, BE)
Assignee: A. Christiaens Societe Anonyme (Brussels, BE)
Filing Date:Jun 09, 1976
Application Number:05/694,421
Claims:1. A compound of the following structure: ##STR8## in which X represents an oxy or thio group; R.sub.1 represetns a group of the formula: ##STR9## wherein R.sub.3 represents a C.sub.1 -C.sub.4 -alkyl, cyclohexyl, unsubstituted phenyl or substituted phenyl group, or R.sub.1 represents a group of the formula:

wherein R.sub.4 represents a C.sub.1 -C.sub.4 -alkyl group or an unsubstituted or substituted phenyl group; R', R" and R'" represent each hydrogen or a substituent selected from the group comprising the halogen atoms, the trifluoromethyl group and the C.sub.1 -C.sub.4 -alkyl groups, as well as the pyridine N-oxide of the compounds of Formula I and the pharmaceutically acceptable base and acid addition salts of said compounds.

2. A compound according to claim 1, in which X is a thio group, R.sub.1 is acetyl, propionyl, parachlorobenzoyl or a R.sub.3 -carbamyl group, and one of the symbols R', R" and R'" represent 3-methyl or one or two of the symbols R', R", and R'" represent chlorine, the other being hydrogen.

3. A compound according to claim 1, in which X is a thio group, R.sub.1 is acetyl, propionyl, para-chlorobenzoyl or a R.sub.3 -carbamyl group, and one of the symbols R', R" and R'" represent 3-trifluoromethyl or 4-methyl, the others being hydrogen.

4. 4-(3'-chlorophenoxy)-3-R.sub.3 -carbamylsulfonamidopyridines according to claim 1.

5. 4-(3'-trifluoromethylthiophenoxy)-3-alkylcarbamylsulfonamidopyridines.

6. Pharmaceutical compositions containing a hypo-uricemic or hypo-lipemic effective amount of at least one compound according to claim 1 as active ingredient, together with a pharmaceutical carrier or vehicle.
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