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Details for Patent: 4,053,639

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Details for Patent: 4,053,639

Title: Therapeutically active phenylalkane derivatives
Abstract:2-(2-Fluoro-4-biphenylyl)propan-1-ol, 2-(2'-Fluoro-4-biphenylyl)propan-1-ol and 2-(2,2'-Difluoro-4-biphenylyl)propan-1-ol Possessing great anti-inflammatory, analgesic and antipyretic activities.
Inventor(s): Adams; Stewart Sanders (Nottingham, EN), Armitage; Bernard John (Nottingham, EN), Nicholson; John Stuart (Nottingham, EN), Blancafort; Antonio Ribera (Madrid, ES)
Assignee: The Boots Company Limited (Nottingham, EN)
Filing Date:Oct 04, 1973
Application Number:05/391,759
Claims:1. A compound selected from the group consisting of

2-(2-fluoro-4-biphenylyl)propan-1-ol,

2-(2'-fluoro-4-biphenylyl)propan-1-ol and

2-(2,2'-difluoro-4-biphenylyl)propan-1-ol

2. 2-(2-Fluoro-4-biphenylyl)propan-1-ol

3. 2-(2'-Fluoro-4-biphenylyl)propan-1-ol

4. 2-(2,2'-Difluoro-4-biphenylyl)propan-1-ol

5. A therapeutic composition useful in the treatment of pain, inflammation and pyretic conditions which comprises a compound selected from the group consisting of 2-(2-fluoro-4-biphenylyl)propan-1-ol, 2-(2'-fluoro-4-biphenylyl)propan-1-ol and 2-(2,2'-difluoro-4-biphenylyl)propan-1-ol in association with a pharmaceutically acceptable excipient the amount of said compound present in said composition being an effective amount.

6. A method of treating inflammatory conditions which comprises administering to a subject affected with inflammation an effective amount of a compound selected from the group consisting of 2-(2-fluoro-4-biphenylyl)propan-1-ol, 2-(2'-fluoro-4-biphenylyl)propan-1-ol and 2-(2,2'-difluoro-4-biphenylyl)propan-1-ol.

7. A method of treating conditions of pain which comprises administering to a subject suffering from pain an effective amount of a compound selected from the group consisting of 2-(2-fluoro-4-biphenylyl)propan-1-ol, 2-(2'-fluoro-4-biphenylyl)propan-1-ol and 2-(2,2'-difluoro-4-biphenylyl)propan-1-ol.

8. A method of treating pyretic conditions which comprises administering to a subject suffering from pyrexia an effective amount of a compound selected from the group consisting of

2-(2-fluoro-4-biphenylyl)propan-1-ol,

2-(2'-fluoro-4-biphenylyl)propan-1-ol and

2-(2,2'-difluoro-4-biphenylyl)propan-1-ol.
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