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Details for Patent: 4,051,233

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Details for Patent: 4,051,233

Title: 2-Naphthylacetic acid derivatives and compositions and methods thereof
Abstract:2-Naphthyl acetic acid derivatives and the corresponding amides, esters, hydroxamic acids and addition salts thereof, optionally substituted at the .alpha.-position on the acetic acid moiety and/or at position 6 and/or at positions 1, 4, 7 or 8 on the naphthyl ring and optionally saturated at positions 3 and 4, are anti-inflammatory, analgesic, anti-pyretic and anti-pruritic agents. A pharmaceutical method of effecting treatment of inflammation, pain, pyrexia and pruritus by the administration of naphthyl acetic acid derivatives. A pharmaceutical composition for use in the treatment of the above maladies comprising a naphthyl acetic acid derivative.
Inventor(s): Fried; John H. (Palo Alto, CA), Harrison; Ian T. (Palo Alto, CA)
Assignee: Syntex Corporation (Palo Alto, CA)
Filing Date:May 10, 1976
Application Number:05/684,993
Claims:1. A compound selected from the group of compounds represented by the formula: ##STR9## wherein R.sup.4 is aryl, and the corresponding esters, and pharmaceutically accepted addition salts thereof.

2. The compound of claim 1 wheren R.sup.4 is phenyl.

3. 6-Phenyl-2naphthylacetic acid.

4. A method of effecting treatment of inflammation, pain, pyrexia, and pruritus which comprises administering an effective therapeutic dose of a compound selected from the group of compounds represented by the formula: ##STR10## wherein R.sup.18 is aryl, or a corresponding ester or pharmaceutically acceptable addition salts thereof.

5. The method of claim 4 wherein R.sup.18 is phenyl.

6. The method of claim 4 wherein said compound is 6-phenyl-2-naphthylacetic acid.

7. A pharmaceutical composition for use in effecting treatment of inflammation, pain, fever, and itching which comprises a pharmaceutically acceptable non-toxic excipient and a therapeutically effective amount of a compound represented by the formula: ##STR11## wherein R.sup.18 is aryl, or a corresponding ester or pharmaceutically acceptable addition salt thereof.

8. The pharmaceutical composition of claim 3 wherein R.sup.18 is phenyl.

9. The pharmaceutical composition of claim 3 wherein said compound is 6-phenyl-2-naphthylacetic acid.
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