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|Title:||Esters of tetrahydronaphthyloxy-aminopropanols|
|Abstract:||Compounds having the formula ##STR1## wherein R.sup.1 is lower alkyl; R.sup.3, R.sup.4, R.sup.5, R.sup.6, and R.sup.7 are the same or different and are hydrogen or lower alkyl; R.sup.8, R.sup.9, and R.sup.10 are the same or different and are hydrogen, lower alkyl, lower alkoxy or cycloalkyl; and R.sup.11 is acyl; are useful in the treatment of coronary diseases.|
|Inventor(s):||Hauck; Frederic P. (Somerville, NJ), Cimarusti; Christopher M. (Hamilton, NJ), Narayanan; Venkatachala L. (Hightstown, NJ)|
|Assignee:||E. R. Squibb & Sons, Inc. (Princeton, NJ)|
|Filing Date:||Nov 06, 1975|
|Claims:||1. A compound having the formula ##STR18## or a pharmaceutically acceptable salt thereof, wherein R.sup.1 is lower alkyl; R.sup.3, R.sup.4, R.sup.5, R.sup.6 and R.sup.7 are the same or different and are hydrogen or lower alkyl; R.sup.8, R.sup.9 and R.sup.10 are the same or different and are hydrogen, lower alkyl, lower alkoxy, or monocyclic cycloalkyl having 3 to 6 carbon atoms; and R.sup.11 is an acyl group of the type ##STR19## wherein n is an integer of from 1 to 11, ##STR20## wherein X is monocyclic aryl, or ##STR21## wherein Z is monocyclic aryl-lower alkyl; wherein lower alkyl and lower alkoxy are groups having 1 to 8 carbon atoms and monocyclic aryl is phenyl, lower alkyl phenyl, di(lower alkyl)-phenyl, halophenyl, nitrophenyl, dinitrophenyl, or trinitrophenyl. |
2. A compound in accordance with claim 1 wherein R.sup.3, R.sup.4, R.sup.5, R.sup.6, R.sup.7, R.sup.8, R.sup.9 and R.sup.10 are hydrogen.
3. A compound in accordance with claim 2 wherein R.sup.1 is isopropyl.
4. A compound in accordance with claim 3 wherein R.sup.11 is ##STR22##
5. A compound in accordance with claim 3 wherein R.sup.11 is ##STR23##
6. A compound in accordance with claim 3 wherein R.sup.11 is ##STR24##
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