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Details for Patent: 4,021,572

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Details for Patent: 4,021,572

Title: Prophylactic and therapeutic treatment of acne vulgaris utilizing lactamides and quaternary ammonium lactates
Abstract:Preventive as well as therapeutic treatment of acne vulgaris (hereafter referred to as acne) consisting of the topical application of a solution, lotion or cream containing one or more than one of the lactamides and/or quaternary ammonium lactates is disclosed. Topical application to uninvolved or involved skin has been found to achieve respectively a complete prevention or a substantial remission of acne.
Inventor(s): Van Scott; Eugene J. (Rydal, PA), Yu; Ruey J. (Philadelphia, PA)
Assignee:
Filing Date:Jul 23, 1975
Application Number:05/598,224
Claims:1. A non-irritating therapeutic composition for alleviating the symptoms of acne in humans and for preventing the recurrence thereof comprising: as an active ingredient, a therapeutically effective amount of a product prepared by reacting, in aqueous or alcoholic aqueous solution at room temperature, lactic acid or lactic anhydride and a base selected from the group consisting ammonium hydroxide, an organic primary, secondary, or tertiary alkylamine, alkanol amine, diamine, dialkylamine, dialkanolamine, alkylalkanol amine, trialkylamine, trialkanol amine, dialkyl alkanol amine, and alkyl dialkanolamine wherein the alkyl or alkanol substituent has from 1 to 8 carbon atoms, in a pharmaceutically acceptable vehicle for topical application.

2. The composition of claim 1 wherein the active ingredient is present in a concentration of from 1 up to about 20 percent by volume of the total composition.

3. The composition of claim 1 wherein the active ingredient is present in a concentration of from 2 up to about 10 percent by volume of the total composition.

4. The composition of claim 1 wherein the active ingredient comprises a product prepared by reacting lactic acid or lactic anhydride and a member selected from the group consisting of ammonium hydroxide, methylamine, ethylamine, monoethanolamine, monoisopropanolamine, ethylenediamine, 1,2-diaminopropane, dimethylamine, diethanolamine, diisopropanolamine, N-methylethanolamine, N-ethylethanolamine, trimethylamine, triethylamine, triethanolamine, N-methyldiethanolamine, and triisopropylamine.

5. The composition of claim 1 wherein the active ingredient comprises a product prepared by reacting lactic acid or lactic anhydride and a member selected from the group consisting of ammonium hydroxide, methylamine, ethylamine, propylamine, butylamine, monoethanolamine, monoisopropanolamine, ethylenediamine, 1,2-diaminopropane, 1,3-diaminopropane, N-ethanolethylenediamine, dimethylamine, diethylamine, diethanolamine, diisopropanolamine, N-methylethanolamine, N-ethylethanolamine, trimethylamine, triethylamine, triethanolamine, N-methyldiethanolamine, N,N-diethanolamine, N-ethyldiethanolamine, N-N-dimethylethanolamine, triisopropanolamine, and N-N-dioctylethanolamine.

6. The composition of claim 1 wherein the vehicle is at least one member selected from the group consisting of water, ethanol, and propylene glycol present therein in a concentration of up to 99, 70, and 30 percent, respectively.

7. The composition of claim 1 wherein the pH thereof is from about 3 to about 8.

8. The composition of claim 1 wherein the pH thereof is from about 3.5 to about 7.

9. A non-irritating therapeutic composition for alleviating the symptoms of acne in humans and for preventing the recurrence thereof comprising, in approximate parts by volume: a product prepared by reacting, in aqueous or alcoholic aqueous solution at room temperature, 11 parts lactic acid, and 7 parts concentrated ammonium hydroxide solution admixed with 10 parts water, 50 parts ethanol, and 10 parts propylene glycol diluted with sufficient additional water to make 100 parts of said composition.

10. A nonirritating therapeutic composition for alleviating the symptoms of acne in humans and for preventing the recurrence thereof comprising, in approximate parts by volume: a product prepared by reacting, in aqueous or alcoholic aqueous solution at room temperature, 5 parts lactic acid, and 2.5 parts ethanolamine admixed with 10 parts water, 50 parts ethanol, and 20 parts propylene glycol, diluted with sufficient water to make 100 parts of said composition.

11. A non-irritating composition for alleviating the symptoms of acne in humans and for preventing the recurrence thereof comprising, in approximate parts by volume: a product prepared by reacting, in aqueous or alcoholic aqueous solution at room temperature, 5 parts lactic acid, and 4 parts diethanolamine admixed with 10 parts water, 50 parts ethanol, and 20 parts propylene glycol, diluted with sufficient water to make 100 parts of said composition.

12. A non-irritating therapeutic composition for alleviating the symptoms of acne in humans and for preventing the recurrence thereof comprising, in admixture: an ointment base comprising, in approximate parts by weight, 50 parts polyoxyethylene (20) sorbitan monooleate, 220 parts cetyl alcohol, 4 parts cholesterol, and 2 parts squalene; and a liquid comprising, in approximate parts by volume, 550 parts water, 100 parts propylene glycol, admixed with a product prepared, by reacting, in aqueous or alcoholic aqueous solution at room temperature, 50 parts lactic acid and 20 parts ethanolamine, said base and liquid being present in a weight-volume ratio of 276 grams of said base to 720 mls of said liquid.

13. A non-irritating therapeutic composition for alleviating the symptoms of acne in humans and for preventing the recurrence thereof comprising, in admixture: an ointment base comprising, in approximate parts by weight, 50 parts polyoxyethylene (20) sorbitan monooleate, 150 parts cetyl alcohol, 50 parts stearyl alcohol, 5 parts squalene and 5 parts cholesterol; and a liquid comprising, in approximate parts by volume, 560 parts water, 20 parts mannitol and 100 parts propylene glycol, admixed with a product prepared by reacting, in aqueous or alcoholic aqueous solution at room temperature, 40 parts lactic acid, and 20 parts ethanolamine, said base and said liquid present in a weight-volume ratio of 260 grams base to 740 mls liquid.

14. A non-irritating therapeutic composition for treatment of the symptoms of acne in humans and for preventing the recurrence thereof comprising, in admixture: an ointment base comprising, in approximate parts by weight, 50 parts Tween 80, 150 parts cetyl alcohol, 50 parts stearyl alcohol, 5 parts squalene and 5 parts cholesterol; and a liquid comprising, in approximate parts by volume, 560 parts water, 100 parts propylene glycol, 40 parts lactic acid, 20 parts ethanolamine, and 20 parts mannitol, said base and said liquid present in a weight-volume ratio of 260 grams base to 740 mls liquid.

15. A non-irritating method for alleviating the symptoms of acne in humans and for preventing the recurrence thereof comprising: topically applying to involved areas of the body and to areas thereof susceptible to acne lesions, an effective amount of a composition comprising: a therapeutically effective amount of a product prepared by reacting, in aqueous or alcoholic aqueous solution at room temperature, lactic acid or lactic anhydride and a base selected from the group consisting of ammonium hydroxide, an organic primary, secondary, or tertiary alkylamine, alkanolamine, diamine, dialkylamine, dialkanolamine, alkylalkanolamine, trialkylamine, trialkanol amine, Dialkyl alkanol amine, or alkyl dialkanolamine wherein the alkyl or alkanol substituent has from 1 to 8 carbon atoms, in a pharmaceutically acceptable vehicle.

16. The method of claim 15 wherein the reaction product is present in a concentration of from 1 up to about 20 percent by volume of the total composition.

17. The method of claim 15 wherein the reaction product is present in a concentration of from 2 up to about 10 percent by volume of the total composition.

18. The method of claim 15 wherein the product comprises a product prepared by reacting lactic acid or lactic anhydride and a member selected from the group consisting of ammonium hydroxide, methylamine, ethylamine, monoethanolamine, monoisopropanolamine, ethylenediamine, 1,2-diaminopropane, dimethylamine, diethylamine, diethanolamine, diisopropanolamine, N-methylethanolamine, N-ethylethanolamine, triethylamine, triethanolamine, N-methyldiethanolamine, and triisopropylamine.

19. The method of claim 15 wherein the product comprises a product prepared by reacting lactic acid or lactic anhydride and a member selected from the group consisting of ammonium hydroxide, methylamine, ethylamine, propylamine, butylamine, monoethanolamine, monoisopropanolamine, ethylenediamine, 1,2-diaminopropane, 1,3-diaminopropane, N-ethanolethylenediamine, dimethylamine, diethylamine, diethanolamine, diisopropanolamine, N-methylethanolamine, N-ethylethanolamine, trimethylamine, triethylamine, triethanolamine, N-methyldiethanolamine, N,N-diethanolamine, N-ethyldiethanolamine, N-N-dimethylethanolamine, triisopropanolamine, and N,N-dioctylethanolamine.

20. The method of claim 15 wherein the vehicle is at least one member selected from the group consisting of water, ethanol, and propylene glycol present therein in a concentration of up to 99, 70, and 30 percent, respectively.

21. The method of claim 15 wherein the pH thereof is from about 3 to about 8.

22. The method of claim 15 wherein the pH thereof is from about 3.5 to about 7.

23. A non-irritating method for alleviating the symptoms of acne in humans and for preventing the recurrence thereof comprising: topically applying to involved areas of the body and to areas thereof susceptible to acne lesions an effective amount of the composition comprising in approximate parts by volume: a product prepared by reacting, in aqueous or alcoholic aqueous solution at room temperature, 11 parts lactic acid, and 7 parts concentrated ammonium hydroxide admixed with 10 parts water, 50 parts ethanol, and 10 parts propylene glycol, diluted with sufficient additional water to make 100 parts of said composition.

24. A non-irritating method for alleviating the symptoms of acne in humans and for preventing the recurrence thereof comprising: topically applying to involved areas of the body and to areas thereof susceptible to acne lesions an effective amount of a composition comprising in approximate parts by volume: a product prepared by reacting, in aqueous or alcoholic aqueous solution at room temperature, 5 parts lactic acid, and 2.5 parts ethanolamine admixed with 10 parts water, 50 parts ethanol, and 20 parts propylene glycol, diluted with sufficient water to make 100 parts of said composition.

25. A non-irritating method for alleviating the symptoms of acne in humans and for preventing the recurrence thereof comprising: topically applying to involved areas of the body and to areas thereof susceptible to acne lesions an effective amount of a composition comprising, in approximate parts by volume: a product prepared by reacting, in aqueous or alcoholic aqueous solution at room temperature, 5 parts lactic acid, and 4 parts diethanolamine admixed with 10 parts water, 50 parts ethanol, and 20 parts propylene glycol, diluted with sufficient water to make 100 parts of said composition.

26. A non-irritating method for alleviating the symptoms of acne in humans and for preventing the recurrence thereof comprising: topically applying to involved areas of the body and to areas thereof susceptible to acne lesions an effective amount of a composition comprising, in admixture: an ointment base comprising in approximate parts by weight, 50 parts polyoxyethylene (20) sorbitan monooleate, 220 parts cetyl alcohol, 4 parts cholesterol, and 2 parts squalene; and a liquid comprising in approximate parts by volume, 550 parts water, and 1-0 parts propylene glycol, admixed with a product prepared by reacting, in aqueous or alcoholic aqueous solution at room temperature, 50 parts lactic acid, and 20 parts ethanolamine, said base and liquid being present in a weight-volume ratio of 276 grams of said base to 720 mls of said liquid.

27. A non-irritating method for alleviating the symptoms of acne in humans and for preventing the recurrence thereof comprising: topically applying to involved areas of the body and to areas thereof susceptible to acne lesions an effective amount of a composition comprising, in admixture: an ointment base comprising, in approximate parts by weight, 50 parts polyoxyethylene (20) sorbitan monooleate, 150 parts cetyl alcohol, 50 parts stearyl alcohol, and 5 parts squalene, and a liquid comprising, in approximate parts by volume, 570 parts water, 20 parts mannitol and 100 parts propylene glycol, admixed with a product prepared by reacting, in aqueous or alcoholic aqueous solution at room temperature, 30 parts lactic acid and 25 parts triethanolamine, said base and said liquid being present in a weight-volume ratio of 255 grams base to 745 mls liquid.

28. A non-irritating method for alleviating the symptoms of acne in humans and for preventing the recurrence thereof comprising: topically applying to involved areas of the body and to areas thereof susceptible to acne lesions an effective amount of a composition comprising, in admixture, an ointment base comprising, in approximate parts by weight, 50 parts polyoxyethylene (20) sorbitan monooleate, 150 parts cetyl alcohol, 50 parts stearyl alcohol, 5 parts squalene, and 5 parts cholesterol, and a liquid comprising, in approximate parts by volume, 560 parts water, 20 parts mannitol, and 100 parts propylene glycol, admixed with a product prepared by reacting, in aqueous or alcoholic aqueous solution at room temperature, 40 parts lactic acid, and 20 parts ethanolamine, said base and liquid present in a weight-volume ratio of 260 grams base to 740 mls liquid.
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