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Generated: November 21, 2017

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Title: Topical clindamycin preparations
Abstract:Disclosed is an anti-inflammatory compound, 6.alpha.,9.alpha.-di-fluoro-11.beta.,17.alpha.,21-trihydroxy-16.beta.-meth ylpregna-1,4-diene-3,20-dione 17,21-diacetate, and topical pharmaceutical formulations which include antimicrobial agents.
Inventor(s): Ayer; Donald E. (Kalamazoo, MI), Schlagel; Carl A. (Kalamazoo, MI), Flynn; Gordon L. (Ann Arbor, MI)
Assignee: The Upjohn Company (Kalamazoo, MI)
Filing Date:Mar 19, 1976
Application Number:05/668,389
Claims:1. A therapeutic composition for topical or local application for treatment of affected dermatosis comprising an anti-inflammatory therapeutic amount of 6.alpha.,9.alpha.-difluoro-11.beta., 17.alpha.,21-trihydroxy-16.beta.-methylpregna-1,4-diene-3,20-dione 17,21-diacetate, an antibacterial therapeutic amount of clindamycin or pharmaceutically acceptable salt or ester thereof and an antifungal therapeutic amount of chloroxine in association with a pharmaceutical carrier.

2. A therapeutic composition according to claim 1, where the anti-inflammatory therapeutic amount of 6.alpha.,9.alpha.-difluoro-11.beta., 17.alpha.,21-trihydroxy-16.beta.-methylpregna-1,4-diene-3,20-dione 17,21-diacetate is from about 0.01 percent to about 0.1 percent, where the antibacterial therapeutic amount of clindamycin or a pharmaceutically acceptable salt or ester thereof is from about 0.5 percent to about 2 percent and where the antifungal therapeutic amount of chloroxine is from about 1 percent to about 2 percent.

3. A therapeutic composition according to claim 1 where the anti-inflammatory therapeutic amount of 6.alpha.,9.alpha.-difluoro-11.beta., 17.alpha.,21-trihydroxy-16.beta.-methylpregna-1,4-diene-3,20-dione 17,21-diacetate is 0.05 percent, where the antibacterial therapeutic amount of clindamycin or a pharmaceutically acceptable salt or ester thereof is 1 percent and where the antifungal therapeutic amount of chloroxine is not more than 1.5 percent.

4. A therapeutic composition according to claim 3 which is a cream.

5. The therapeutic composition according to claim 3 which is an ointment.

6. A therapeutic composition for topical or local application for treatment of infected dermatoses comprising an anti-inflammatory therapeutic amount of 6.alpha.,9.alpha.-difluoro-11.beta., 17.alpha.,21-trihydroxy-16.beta.-methylpregna-1,4-diene-3,20-dione 17,21-diacetate and an antibacterial therapeutic amount of clindamycin or a pharmaceutically acceptable salt or ester thereof in association with a pharmaceutical carrier.

7. A therapeutic composition according to claim 6 where the anti-inflammatory therapeutic amount of 6.alpha.,9.alpha.-difluoro-11.beta., 17.alpha.,21-trihydroxy-16.beta.-methylpregna-1,4-diene 3,20-dione 17,21-diacetate is from about 0.01 percent to about 0.1 percent and the antibacterial therapeutic amount of clindamycin or a pharmaceutically acceptable salt or ester thereof is from about 0.5 percent to about 2 percent.

8. A therapeutic composition according to claim 7 where the anti-inflammatory therapeutic amount of 6.alpha.,9.alpha.-difluoro-11.beta., 17.alpha.-21-trihydroxy-16.beta.-methylpregna-1,4-diene-3,20-dione 17,21-diacetate if 0.05 percent and the antibacterial therapeutic amount of clindamycin or a pharmaceutically acceptable salt or ester thereof is 1 percent.

9. A therapeutic composition according to claim 8, which is a cream.

10. A therapeutic composition according to claim 8, which is an ointment.
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