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Details for Patent: 4,017,596

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Details for Patent: 4,017,596

Title: Radiopharmaceutical chelates and method of external imaging
Abstract:A chelate of technetium-99m, cobalt-57, gallium-67, gallium-68, indium-111 or indium-113m and a substituted iminodiacetic acid or an 8-hydroxyquinoline useful as a radiopharmaceutical external imaging agent. The invention also includes preparative methods therefor.
Inventor(s): Loberg; Michael Dewey (Baltimore, MD), Callery; Patrick Stephen (Timonium, MD), Cooper; Malcolm (Reisterstown, MD)
Assignee: Research Corporation (New York, NY)
Filing Date:Sep 02, 1975
Application Number:05/609,545
Claims:1. A chelate of technetium-99m, cobalt-57, gallium-67, gallium-68, indium-111 or indium-113m and a substituted iminodiacetic acid.

2. A chelate of technetium-99m cobalt-57, gallium-67, gallium-68, indium-111 or indium-113m and an 8-hyroxyquinoline.

3. A composition comprising a mixture of the technetium-99m chelate of claim 1 and the stannous chelate of said chelating agent.

4. A composition comprising a mixture of the technetium-99m chelate of claim 1, the stannous chelate of said chelating agent and said chelating agent.

5. The chelate of claim 1 wherein said iminodiacetic acid chelating agent is N-methyliminodiacetic acid, N-[N'-(2,6-dimethylphenyl) carbamoylmethyl] iminodiacetic acid, N-(10-carboxydecyl) iminodiacetic acid, N-(O-bromobenzyl) iminodiacetic acid, N-[3-(1-naphthyloxy)-2-hydroxypropyl] iminodiacetic acid, nitrilo-triacetic acid or 2,6-pyridinedicarboxylic acid.

6. N-[N'(2,6-dimethylphenyl) carbamoylmethyl] iminodiacetic acid.

7. A method of external imaging which includes the intravenous administration of a solution adapted for intravenous administration containing the chelate of claim 1.

8. A method of external imaging which includes the intravenous administration of a solution adapted for intravenous administration containing the chelate of claim 2.

9. A method of preparing the chelate of claim 1 comprising reacting said radio-isotope with said chelating agent.

10. The method of claim 9 wherein said radioisotope is technetium-99m.

11. The method of claim 10 wherein said chelate is prepared by reducing a pertechnetrate in the presence of said chelating agent.

12. The method of claim 11 wherein said reduction is effected utilizing stannous chloride as a reducing agent.

13. A method of preparing the chelate of claim 2 comprising reacting said radio-isotope with said chelating agent.
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