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Details for Patent: 4,005,188

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Details for Patent: 4,005,188

Title: X-ray contrast media
Abstract:This invention relates to compounds of the formula: ##STR1## in which: R.sub.1 represents a hydrogen atom or a radical of the formula ##STR2## in which R.sub.4 and R.sub.5 represent, independently of each other, a hydrogen atom or a lower alkyl radical, R.sub.2 represents a hydrogen atom or a lower alkanoyl radical, R.sub.3 represents a hydrogen atom, a lower alkyl radical or a lower alkanoyl radical, n is 3 or 4, And their lower alkyl esters and their salts with pharmaceutically acceptable bases. Said compounds are useful as X-ray contrast media.
Inventor(s): Tilly; Guy (Aulnay-sous-Bois, FR), Hardouin; Michel Jean Charles (Aulnay-sous-Bois, FR), Lautrou; Jean (Aulnay-sous-Bois, FR)
Assignee: Laboratoires Andre Guerbet (Aulnay-sous-Bois, FR)
Filing Date:May 20, 1975
Application Number:05/579,280
Claims:1. Compounds of the formula : ##STR8## in which: R.sub.1 is selected from the group consisting of hydrogen and a radical of the formula ##STR9## in which R.sub.4 and R.sub.5, independently of each other, are selected from the group consisting of hydrogen and a lower alkyl radical,

R.sub.2 is selected from the group consisting of hydrogen and a lower alkanoyl radical,

R.sub.3 is selected from the group consisting of hydrogen, a lower alkyl radical and a lower alkanoyl radical, n is 3 or 4,

and their lower alkyl esters and their salts with pharmaceutically acceptable bases.

2. N,N'-bis-(2,4,6 -triiodo-3-N-methylcarbamyl-5-N-methyl-acetamido-benzoyl)lysine and its salts with pharmaceutically acceptable bases.

3.

3. N,N'-bis-(2,4,6-triiodo-3-N-methylcarbamyl-5-acetamido-benzoyl)lysine and its salts with pharmaceutically acceptable bases.

4. N,N'-bis-(2,4,6-triiodo-3-N-methylacetamido-benzoyl)-lysine and its salts with pharmaceutically acceptable bases.

5. An X-ray contrast medium consisting essentially of a compound as claimed in claim 1, in a pharmaceutically acceptable carrier.
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