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Details for Patent: 4,001,322

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Details for Patent: 4,001,322

Title: 3-Substituted phenylalkyl amines
Abstract:Novel 3-phenoxyphenylalkyl amines and the amides, alcohols, tetrazoles, and carbamates related thereto as well as novel intermediates useful in the preparation of such compounds. The compounds of this invention are useful as anti-inflammatory, analgesic, and antipyretic agents.
Inventor(s): Marshall; Winston S. (Indianapolis, IN)
Assignee: Eli Lilly and Company (Indianapolis, IN)
Filing Date:Nov 14, 1975
Application Number:05/632,132
Claims:1. A compound of the formula ##STR47## wherein R.sub.1 is hydrogen, C.sub.1 to C.sub.5 -alkyl, C.sub.2 to C.sub.5 -alkenyl, C.sub.2 -C.sub.5 -alkynyl;

n is an integer of from 0 to 3;

each R.sub.2 is the same or different and is hydrogen, C.sub.1 to C.sub.5 -alkyl, or --CH.sub.2 --COOR.sub.3, where R.sub.3 is hydrogen, C.sub.1 to C.sub.5 -alkyl, or a pharmaceutically acceptable cation;

and the pharmaceutically acceptable acid addition salts thereof.

2. The compound of claim 1 which is 2-(3-phenoxyphenyl)-propionamide.

3. The compound of claim 1 which is N,N-dimethyl-2-(3-phenoxyphenyl)propionamide.

4. The compound of claim 1 which is N-methyl-2-(3-phenoxyphenyl)butyramide.

5. The compound of claim 1 which is N-methyl-2-(3-phenoxyphenyl)propionamide.

6. The compound of claim 1 which is N-methyl-(3-phenoxyphenyl)acetamide.

7. The compound of claim 1 which is N, N-dimethyl-(3-phenoxyphenyl)acetamide.

8. The compound of claim 1 which is 3-(3-phenoxyphenyl)-butyramide.
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