Upgrade to enjoy subscriber-only features like email alerts and data export. See the Plans and Pricing
|Title:||Antiandrogenic agents and method for the treatment of androgen dependent disease states|
|Abstract:||This application relates to certain 4'-substituted and to 3',4'-disubstituted anilides, to methods for their preparation and to methods for their use as antiandrogens. These substituted anilides are useful in the treatment of androgen dependent disease states, such as benign prostatic hypertrophy, hirsutism, acne and the like.|
|Inventor(s):||Neri; Rudolph O. (Hawthorne, NJ), Topliss; John G. (West Caldwell, NJ)|
|Assignee:||Schering Corporation (Kenilworth, NJ)|
|Filing Date:||Sep 11, 1974|
|Claims:||1. A method for the treatment of benign prostatic hypertrophy which comprises administering to mammals suffering from benign prostatic hyperstrophy, an effective quantity for treating benign prostatic hypertrophy of a compound having the structural formula: ##SPC26## |
or the non-toxic pharmaceutically acceptable salts thereof, wherein X is a member of the group consisting of nitro, trifluoromethyl, chloro, bromo and iodo; Y is a member of the group consisting of hydrogen, halogen, nitro, lower alkyl, lower alkoxy, lower alkanoyl, polyfluoroloweralkoxy, polyfluoroloweralkyl, and trifluoromethylthio, with the proviso that when Y and R' are both hydrogen, X is other than iodo; R' is a member of the group consisting of hydrogen and alkyl having less than 5 carbon atoms and R is cyclopropyl, cyclobutyl or branched chain alkyl having up to 8 carbon atoms.
2. A method according to claim 1 wherein R is isopropyl.
3. A method according to claim 2 wherein R' is hydrogen. Y is trifluoromethyl and X is nitro, said compound being 4'-nitro-3'-trifluoromethylisobutyranilide.
4. A method according to claim 2 wherein R' is hydrogen, Y is trifluoromethyl and X is iodo, said compound being 4'-iodo-3'-trifluoromethylisobutyranilide.
5. A method according to claim 1 wherein R is cyclopropyl.
6. A method according to claim 5 wherein R' is hydrogen, Y is trifluoromethyl, and X is nitro, said compound being 4'-nitro-3'-trifluoromethylcyclopropylcarbanilide.
Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verifification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.