Upgrade to enjoy subscriber-only features like email alerts and data export. See the Plans and Pricing

Serving hundreds of leading biopharmaceutical companies globally:

US Army
Johnson and Johnson
Cantor Fitzgerald
Daiichi Sankyo

Generated: June 18, 2018

DrugPatentWatch Database Preview

Details for Patent: 3,991,078

« Back to Dashboard

Title: N-substituted 1,2,4-triazoles
Abstract:Antiviral 1-(G)-1,2,4-triazole carboxamides, thiocarboxamides and carboxamidines wherein G is an acid labile hydrocarbon moiety, e.g., 1-(.alpha.-alkoxyalkyl), are prepared by, e.g., the acid-catalyzed addition reaction of appropriately substituted 1,2,4-triazole and an .alpha.,.beta.-unsaturated ether.
Inventor(s): Witkowski; Joseph T. (Laguna Niguel, CA), Robins; Roland K. (Santa Ana, CA)
Assignee: ICN Pharmaceuticals, Inc. (Irvine, CA)
Filing Date:Mar 18, 1974
Application Number:05/452,213
Claims:1. An N-substituted 1,2,4-triazole of the structure ##SPC3##

wherein R.sub.1 is selected from the group consisting of carboxamido, thiocarboxamido, cyano, carboxamidino and its physiologically acceptable acid-addition salts and alkyl carboxylate groups and wherein G is a moiety of the structure ##SPC4##

wherein R' and R" are alkyl groups having from 1 to 9 carbon atoms or R'

4. A compound according to claim 2 wherein G is selected from the group

5. A compound according to claim 3 wherein G is selected from the group

14. A method of forming acid labile N-substituted 1,2,4-triazoles which comprises effecting the acid-catalyzed addition reaction, under anhydrous conditions, of 1,2,4-triazole of formula ##SPC5##

wherein R.sub.1 is a cyano, carboxamido, thiocarboxamido or alkylcarboxylate group with an .alpha.,.beta.-unsaturated ether of the formula ##STR2## wherein R" is alkyl of 1 to 9 carbons, inclusive, and R'" is hydrogen or alkyl of 1 to 8 carbon atoms, inclusive, or R" and R'", taken together, are dimethylene or trimethylene to form compounds of structure ##SPC6##

wherein G is as defined in claim 1.

For more information try a trial or see the plans and pricing

Serving hundreds of leading biopharmaceutical companies globally:

Federal Trade Commission
US Army
Daiichi Sankyo
US Department of Justice
Farmers Insurance
Argus Health

Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verifification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.