|Title:|| Asthma treatment by inhalation of micronized N,N-diethyl-4-methyl-1-piperazinecarboxamide pamoate|
|Abstract:||Asthma is effectively treated by inhalation of powder dispensed from an aerosol suspension of powdered N,N-diethyl-4-methyl-1-piperazinecarboxamide pamoate, which is dispersed as a fine powder, essentially below 10 microns in particle size, which gives an improved ratio of absorption in the lungs as compared to systemic absorption.|
|Inventor(s):|| Corey, Jr.; Howard Seebree (New City, NY), Barringer; William Charles (Pearl River, NY), Hansen; Lloyd Frank (Campbell Hall, NY) |
|Assignee:|| American Cyanamid Company (Stamford, CT) |
|Filing Date:||Jan 13, 1975|
|Claims:||1. A pressurized dispenser for the treatment of asthma containing a suspension consisting essentially of an effective amount of N,N-diethyl-4-methyl-1-piperazinecarboxamide pamoate having a particle size range of 0.5 microns to 10 microns, about 5% by weight of ethanol and a propelling amount of a low boiling chlorofluoalkane in a container having a metering valve. |
2. The dispenser of claim 1 in which the propellant is dichlorofluoromethane and the container is stainless steel.
3. The dispenser of claim 1 in which the propellant is dichlorofluoromethane and the container is aluminum.