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Generated: December 15, 2017

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Title: Chemical compounds
Abstract:This invention relates to new derivatives of dibenzocycloheptenes and to processes for making them. More particularly, the invention includes 5H-dibenzo[a,d]cycloheptenes and 10,11-dihydro-5H-dibenzo[a,d]cycloheptenes which are substituted at their 5-carbon atom with an aminopropyl or an aminopropylidene radical. The amino entity may be either primary or secondary and if secondary, the substituent may be either a lower alkyl or alkenyl radical having up to 6 carbon atoms, cycloalkyl having up to 8 carbon atoms or an aralkyl radical. The dibenzocycloheptene nucleus may be further substituted. The invention also includes the intermediates used for obtaining these products. Also included are derivatives such as acyl derivatives which yield the active compound under physiological conditions.
Inventor(s): Engelhardt; Edward L. (Gwynedd Valley, PA)
Assignee: Merck & Co., Inc. (Rahway, NJ)
Filing Date:Apr 11, 1975
Application Number:05/567,157
Claims:1. A compound selected from the group consisting of ##SPC10##

and the non-toxic acid addition salts thereof; wherein R.degree. is a lower alkyl, R is a lower alkyl, and Y is hydrogen.

2. 5-(3-Methylaminopropyl)-3-methylsulfonyl-5H-dibenzo[a,d]cycloheptene.

3. 10,11-Dihydro-5-(3-methylaminopropyl)-3-methylsulfonyl-5H-dibenzo[a,d]cy cloheptene.

4. 5-(3-Met hylaminopropylidene)-3-methylsulfonyl-5H-dibenzo[a,d]cycloheptene.

5. 10,11-Dihydro-5-(3-methylaminopropylidene)-3-methylsulfonyl-5H- dibenzo[a,d]cycloheptene.
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