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|Title:||2-Naphthyl acetic acid derivatives|
|Abstract:||2-Naphthyl acetic acid derivatives and the corresponding amides, esters, hydroxamic acids and addition salts thereof, optionally substituted at the .alpha.-position on the acetic acid moiety and/or at position 6 and/or at positions 1, 4, 7 or 8 on the naphthyl ring and optionally saturated at positions 3 and 4, are anti-inflammatory, analgesic, anti-pyretic and anti-pruritic agents. A pharmaceutical method of effecting treatment of inflammation, pain, pyrexia and pruritus by the administration of naphthyl acetic acid derivatives. A pharmaceutical composition for use in the treatment of the above maladies comprising a naphthyl acetic acid derivative.|
|Inventor(s):||Fried; John H. (Palo Alto, CA), Harrison; Ian T. (Palo Alto, CA)|
|Assignee:||Syntex Corporation (Panama, PM)|
|Filing Date:||Aug 05, 1974|
|Claims:||1. A compound selected from the group of compounds represented by the formula: ##SPC11## |
wherein R.sup.4 is cycloalkyl having 3 to 7 carbon atoms; the alkyl esters thereof where the alkyl moiety has 1 to 12 carbon atoms; and the pharmaceutically acceptable addition salts thereof.
2. The compound of claim 1 wherein R.sup.4 is cyclopropyl.
3. The compound of claim 1 wherein said compound of Formula XI is 6-cyclohexyl-2-naphthylacetic acid.
4. 6-Cyclopropyl-2-naphthylacetic acid.
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