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Details for Patent: 3,979,520

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Details for Patent: 3,979,520

Title: Preparation of rapidly resorbable glibenclamide
Abstract:Rapidly resorbable particulate glibenclamide having a particle surface area of active material of at least 3 m.sup.2 /g is produced by precipitating the active material from its solution in an organic solvent or in water or aqueous alcohol, preferably rendered alkaline, using water which is preferably acidified.
Inventor(s): Rothe; Werner (Hockenheim, DT), Heinemann; Helmut (Heidelberg, DT), Schmidt; Felix Helmut (Mannheim-Seckenheim, DT), Betzien; Gunter (Mannheim, DT)
Assignee: Boehringer Mannheim G.m.b.H. (Mannheim, DT)
Filing Date:Sep 20, 1974
Application Number:05/508,001
Claims:1. A process for the preparation of a blood sugar-lowering composition comprising dissolving glibenclamide in a water-miscible organic solvent, combining said solution with water to precipitate out the glibenclamide with a surface area of about 3 to 10 m.sup.2 /g, and combining the precipitated material with about 2 to 100 times its weight of a pharmacologically acceptable dispersion agent.

2. The process of claim 1 wherein the organic solvent is dimethyl formamide, dimethyl sulfoxide or a lower alkanol and the water is acidifed prior to combination with the organic solution.

3. The process of claim 2 wherein the water is acidified with ascorbic acid, acetic acid or citric acid.

4. A process for the preparation of a blood sugar-lowering composition comprising dissolving glibenclamide in alkaline water or aqueous lower alkanol, combining said solution with acidified water to precipitate out the glibenclamide with a surface area of about 3 to 10 m.sup.2 /g, and combining the precipitated material with about 2 to 100 times its weight of a pharmacologically acceptable dispersion agent.

5. The process of claim 4 wherein the water is acidified with ascorbic acid, acetic acid or citric acid.
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