Generated: April 23, 2017
|Title:||Preparation of rapidly resorbable glibenclamide|
|Abstract:||Rapidly resorbable particulate glibenclamide having a particle surface area of active material of at least 3 m.sup.2 /g is produced by precipitating the active material from its solution in an organic solvent or in water or aqueous alcohol, preferably rendered alkaline, using water which is preferably acidified.|
|Inventor(s):||Rothe; Werner (Hockenheim, DT), Heinemann; Helmut (Heidelberg, DT), Schmidt; Felix Helmut (Mannheim-Seckenheim, DT), Betzien; Gunter (Mannheim, DT)|
|Assignee:||Boehringer Mannheim G.m.b.H. (Mannheim, DT)|
|Filing Date:||Sep 20, 1974|
|Claims:||1. A process for the preparation of a blood sugar-lowering composition comprising dissolving glibenclamide in a water-miscible organic solvent, combining said solution with water to precipitate out the glibenclamide with a surface area of about 3 to 10 m.sup.2 /g, and combining the precipitated material with about 2 to 100 times its weight of a pharmacologically acceptable dispersion agent. |
2. The process of claim 1 wherein the organic solvent is dimethyl formamide, dimethyl sulfoxide or a lower alkanol and the water is acidifed prior to combination with the organic solution.
3. The process of claim 2 wherein the water is acidified with ascorbic acid, acetic acid or citric acid.
4. A process for the preparation of a blood sugar-lowering composition comprising dissolving glibenclamide in alkaline water or aqueous lower alkanol, combining said solution with acidified water to precipitate out the glibenclamide with a surface area of about 3 to 10 m.sup.2 /g, and combining the precipitated material with about 2 to 100 times its weight of a pharmacologically acceptable dispersion agent.
5. The process of claim 4 wherein the water is acidified with ascorbic acid, acetic acid or citric acid.
Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verifification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.