|Title:|| 1,2,4-Triazol E-3-carboxamides as antiviral agents|
|Abstract:||The use of 1,2,4-triazole-3-carboxamide and 1,2,4-triazole-3-thiocarboxamide and physiologically compatible salts thereof as antiviral agents is disclosed. A process for synthesizing 1-.beta.-D-ribofuranosyl-1,2,4-triazole-3-carboxamide is also disclosed.|
|Inventor(s):|| Witkowski; Joseph T. (Laguna Niguel, CA), Robins; Roland K. (Santa Ana, CA) |
|Assignee:|| ICN Pharmaceuticals, Inc. (Irvine, CA) |
|Filing Date:||Sep 29, 1975|
|Claims:||1. A process of preparing 1-.beta.-D-ribofuranosyl-1,2,4-triazole-3-carboxamide in which 1,2,4-triazole-3-carboxamide is reacted with the enzyme nucleoside phosphorylase in the presence of ribose-1-phosphate at a pH of from about 5 to about 9 and a temperature of from about 0.degree. to about 50.degree.C. |
2. The process of claim 1 in which said enzyme is utilized a concentration of about 0.015 to about 0.75 mg/ml.
3. The process of claim 2 in which the triazole-3-carboxamide is utilized in a concentration of at least about 5.times.10.sup.-.sup. 5 M and said ribose-1-phosphate at a concentration of at least about 2.times.10.sup..sup.-5 M.
4. The process of claim 2 in which the pH is about 7 to about 8 and the temperature from about 25.degree. to about 35.degree.C.
5. The process of claim 4 in which the concentration of said enzyme is about 0.15 mg/ml.