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|Abstract:||O-HALOBENZYLIDENEAMINOGUANIDINES ARE EMPLOYED AS CENTRAL NERVOUS SYSTEM DEPRESSANTS, AS CARDIOVASCULAR DEPRESSANTS, AND/OR AS ANTIDEPRESSANTS FOR OVERCOMING PSYCHIC DEPRESSION.|
|Inventor(s):||Kodama; Jiro K. (Herne Bay, EN), Haynes; George R. (Modesto, CA), Albert; James R. (Modesto, CA)|
|Assignee:||Shell Oil Company (Houston, TX)|
|Filing Date:||Jan 10, 1972|
|Claims:||1. A method for combatting psychic depression in mammals which comprises administering to a psychically depressed mammal in need of said treatment an effective dosage for combatting the psychic depression of the compound of the formula ##SPC3## |
wherein X is halogen or trifluoromethyl, Y and Z may be the same or different and are hydrogen, halogen, trifluoromethyl or alkyl of 1 to 4 carbon atoms, R, R',R" and R.degree. each hydrogen, alkyl of 1 to 4 carbon atoms, alkenyl of 2 to 4 carbon atoms or alkynyl of 2 to 4 carbon atoms with the proviso that R" and R.degree. may together form an alklene or alkenylene bridge of 2 to 4 carbon atoms, with the further proviso that one of Y and R must be hydrogen, or a pharmaceutically acceptable salt thereof.
2. A method according to claim 1 wherein X and Y each is a middle halogen and Z, R, R', R", R.degree. each is hydrogen and the salt is a hydrohalic acid salt.