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Generated: October 20, 2017

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Title: Therapeutic agents
Abstract:O-HALOBENZYLIDENEAMINOGUANIDINES ARE EMPLOYED AS CENTRAL NERVOUS SYSTEM DEPRESSANTS, AS CARDIOVASCULAR DEPRESSANTS, AND/OR AS ANTIDEPRESSANTS FOR OVERCOMING PSYCHIC DEPRESSION.
Inventor(s): Kodama; Jiro K. (Herne Bay, EN), Haynes; George R. (Modesto, CA), Albert; James R. (Modesto, CA)
Assignee: Shell Oil Company (Houston, TX)
Filing Date:Jan 10, 1972
Application Number:05/216,775
Claims:1. A method for combatting psychic depression in mammals which comprises administering to a psychically depressed mammal in need of said treatment an effective dosage for combatting the psychic depression of the compound of the formula ##SPC3##

wherein X is halogen or trifluoromethyl, Y and Z may be the same or different and are hydrogen, halogen, trifluoromethyl or alkyl of 1 to 4 carbon atoms, R, R',R" and R.degree. each hydrogen, alkyl of 1 to 4 carbon atoms, alkenyl of 2 to 4 carbon atoms or alkynyl of 2 to 4 carbon atoms with the proviso that R" and R.degree. may together form an alklene or alkenylene bridge of 2 to 4 carbon atoms, with the further proviso that one of Y and R must be hydrogen, or a pharmaceutically acceptable salt thereof.

2. A method according to claim 1 wherein X and Y each is a middle halogen and Z, R, R', R", R.degree. each is hydrogen and the salt is a hydrohalic acid salt.
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