Upgrade to enjoy subscriber-only features like email alerts and data export. See the Plans and Pricing

Serving hundreds of leading biopharmaceutical companies globally:

Johnson and Johnson
Federal Trade Commission

Generated: April 23, 2018

DrugPatentWatch Database Preview

Details for Patent: 3,971,819

« Back to Dashboard

Title: 3-Amino, 4-thio-substituted, 5-sulphamyl-benzoic acid derivatives
Abstract:This invention relates to new, therapeutically active compounds of the general formula ##SPC1## In which A represents one of the groupings ##EQU1## R.sup.2 --O--, R.sup.2 --S--, R.sup.2 --OS--, and R.sup.2 --O.sub.2 S--, R.sup.1, R.sup.2, R.sup.3, and R.sup.4 each represents hydrogen, an aliphatic radical, a cycloaliphatic radical, or an aromatically, cycloaliphatically, or heterocyclically substituted aliphatic radical, in addition to which R.sup.2 and R.sup.3 may each represent an aromatic or heterocyclic radical, and when A is ##EQU2## R.sup.1 and R.sup.2 may be linked to form a 5- to 8-membered heterocyclic ring system, which may have one or more nitrogen atoms, sulphur atoms, or oxygen atoms in addition to the nitrogen atom linked to R.sup.1 and R.sup.2 ; R.sup.5 is hydrogen or lower alkyl; and R.sup.6 is hydrogen or lower alkyl or acyl; to salts, esters, and amides of the said compounds; and to methods for the production of the compounds.
Inventor(s): Feit; Peter Werner (Gentofte, DK)
Assignee: Lovens Kemiske Fabrik Produktionsaktieselskab (Ballerup, DK)
Filing Date:Nov 15, 1973
Application Number:05/416,163
Claims:1. A compound of the formula ##SPC5##

in which A is R.sup.2 -- S --, R.sup.2, R.sup.3, and R.sup.4 are saturated or unsaturated aliphatic hydrocarbon radicals having from 1 to 7 carbon atoms, cycloalkyl and cycloalkenyl radicals having from 3-8 carbon atoms, phenyl-lower alkyl radicals having from 7 to 10 carbon atoms or cycloalkyl -- lower alkyl radicals having from 4 to 12 carbon atoms, R.sup.2 and R.sup.3 may also be mono- or bi-cyclic carbocyclic aryl radicals, R.sup.5 is a lower alkyl radical, R.sup.6 is a lower alkyl radical or a lower alkanoyl groups, R.sup.3, R.sup.4, R.sup.5 and R.sup.6 may also be a hydrogen atom, R.sup.2 may also be substituted with chlorine, fluorine, methyl, trifluoromethyl, carboxy, carbethoxy, dimethyl amino, hydroxy, methoxy, benzyloxy, or sulfamyl groups and R.sup.4 may be substituted with chlorine, methyl, and methoxy groups; pharmaceutically acceptable salts thereof, and esters thereof with lower alkanols, phenol, cyanomethanol or benzyl alcohol.

2. 3-n-Butylamino-4-phenyl-thio-5-sulfamyl-benzoic acid, a pharmaceutically acceptable salt thereof or an ester thereof with a lower alkanol, phenol, cyanomethanol or benzyl alcohol.

3. 3-Benzylamino-4-phenylthio-5-sulfamyl-benzoic acid, a pharmaceutically acceptable salt thereof or an ester thereof with a lower alkanol, phenol, cyanomethanol or benzyl alcohol.

For more information try a trial or see the plans and pricing

Serving hundreds of leading biopharmaceutical companies globally:

US Army
US Department of Justice
Express Scripts

Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verifification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.