.

Deeper Knowledge, Faster

  • Identify first generic entrants
  • Uncover prior art in expired and abandoned patents
  • Drug patents in 130+ countries

Upgrade to enjoy subscriber-only features like email alerts and data export. See the Plans and Pricing

Serving leading biopharmaceutical companies globally:

Healthtrust
Johnson and Johnson
Argus Health
Dow
McKesson
McKinsey
Farmers Insurance
Julphar
Queensland Health
Baxter

Generated: December 13, 2017

DrugPatentWatch Database Preview

Details for Patent: ► Subscribe

« Back to Dashboard

Details for Patent: ► Subscribe

Title: Substituted indenyl acetic acids
Abstract:New substituted indenyl acetic acids and nontoxic pharmaceutically acceptable amides, esters and salts derived therefrom. The substituted indenyl acetic acids disclosed herein have anit-inflammatory, anti-pyretic and analgesic activity.
Inventor(s): Shen; Tsung-Ying (Westfield, NJ), Greenwald; Richard B. (Framingham, MA), Jones; Howard (Holmdel, NJ), Linn; Bruce O. (Somerville, NJ), Witzel; Bruce E. (Westfield, NJ)
Assignee: Merck & Co., Inc. (Rahway, NJ)
Filing Date:Aug 23, 1974
Application Number:05/499,870
Claims:1. A compound of the formula ##SPC2##

wherein:

Ar is phenyl;

R.sub.1 is hydrogen, C.sub.1.sub.-5 loweralkyl or halogenated C.sub.1.sub.-5 loweralkyl;

R.sub.2 is hydrogen or C.sub.1.sub.-5 loweralkyl;

R.sub.3, r.sub.4, r.sub.5 and R.sub.6 are each hydrogen, C.sub.1.sub.-5 loweralkyl, C.sub.1.sub.-5 loweralkanoyloxy, benzyloxy, C.sub.1.sub.-5 loweralkoxy, nitro, amino, C.sub.1.sub.-5 loweralkanoylamino, benzoylamino, C.sub.1.sub.-5 loweralkylamino, di-C.sub.1.sub.-5 loweralkylamino, di-C.sub.1.sub.-5 loweralkylaminoalkyl, sulfamyl, C.sub.1.sub.-5 loweralkylthio, mercapto, halogen, hydroxy, hydroxy C.sub.1.sub.-5 loweralkyl, C.sub.1.sub.-5 loweralkylsulfonyl, carboxyl, carb C.sub.1.sub.-5 loweralkoxy, carbamido, halogeno C.sub.1.sub.-5 loweralkyl, at least one of R.sub.3 -R.sub.6 being C.sub.1.sub.-5 loweralkanoyloxy, benzoyloxy, C.sub.1.sub.-5 loweralkanoylamino or benzoylamino;

R.sub.7 may be C.sub.1.sub.-5 loweralkyl or C.sub.1.sub.-5 loweralkylsulfonyl;

R.sub.8 may be hydrogen, halogen, hydroxy, C.sub.1.sub.-5 loweralkoxy or halo C.sub.1.sub.-5 loweralkyl; and

M may be hydroxy, C.sub.1.sub.-5 loweralkoxy and the pharmaceutically acceptable acid salts.

2. The compound of claim 1 wherein

R.sub.1 is hydrogen;

R.sub.2 is methyl;

R.sub.3, r.sub.5 and R.sub.6 are each hydrogen;

R.sub.4 is acetoxy;

R.sub.7 is p-methylsulfinyl;

R.sub.8 is hydrogen; and

M is hydroxy.

3. The compound of claim 1 wherein

R.sub.1 is hydrogen or C.sub.1.sub.-5 loweralkyl;

R.sub.2 is C.sub.1.sub.-5 loweralkyl;

R.sub.3, r.sub.4, r.sub.5 and R.sub.6 are each hydrogen, C.sub.1.sub.-5 loweralkanoyloxy, benzoyloxy, C.sub.1.sub.-5 loweralkanoylamino, benzoylamino, fluoro, C.sub.1.sub.-5 loweralkoxy or di-C.sub.1.sub.-5 loweralkylamino, no more than two of R.sub.3, R.sub.4, R.sub.5 and R.sub.6 being other than hydrogen;

R.sub.7 is methylsulfinyl or methylsulfonyl;

R.sub.8 is hydrogen; and

M is hydroxy or C.sub.1.sub.-5 loweralkoxy.

4. The compound of claim 3 wherein

R.sub.1 is hydrogen;

R.sub.2 is C.sub.1.sub.-5 loweralkyl;

R.sub.7 is methylsulfinyl; and

M is hydroxy.

5. The compound of claim 4 wherein

R.sub.3 and R.sub.6 are each hydrogen;

R.sub.4 and R.sub.5 are each hydrogen, C.sub.1.sub.-5 loweralkanoyloxy, fluoro, C.sub.1.sub.-5 loweralkoxy, di-C.sub.1.sub.-5 loweralkylamino, C.sub.1.sub.-5 loweralkanoylamino or benzoylamino.
« Back to Dashboard

For more information try a trial or see the plans and pricing

Serving leading biopharmaceutical companies globally:

US Department of Justice
Farmers Insurance
Moodys
Merck
QuintilesIMS
Daiichi Sankyo
Mallinckrodt
Fuji
Novartis
Cerilliant

Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verifification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.

Copyright 2002-2017 thinkBiotech LLC
ISSN: 2162-2639

Secure SSL Encrypted
Privacy and Cookies
Terms & Conditions

Follow DrugPatentWatch:

botpot