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|Title:||Isoxazole intermediate compounds|
|Abstract:||A process for the synthesis of N-aryl-3,4-dihydro-2-alkyl-4-oxo-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxides by treatment of N-aryl-N'-alkyl-N'-(2'-alkoxycarbonylbenzenesulfonyl)glycineamides, useful intermediates for said process, with an alkali or alkaline earth metal hydride in a reaction-inert solvent at 50.degree.-150.degree.C., said products being antiinflammatory agents.|
|Inventor(s):||Lombardino; Joseph G. (Niantic, CT)|
|Assignee:||Pfizer Inc. (New York, NY)|
|Filing Date:||Apr 04, 1975|
|Claims:||1. A compound of the formula: ##SPC8## |
wherein R.sub.1 is 5-methyl-3-isoxazolyl;
R.sub.2 is alkyl having from 1 to 3 carbon atoms;
X is selected from the group consisting hydrogen, methyl, methoxy, fluoro, chloro and bromo and
R.sub.3 is alkyl having 1 to 3 carbon atoms.
2. A compound of claim 1 wherein X is hydrogen and R.sub.2 and R.sub.3 are methyl.