Upgrade to enjoy subscriber-only features like email alerts and data export. See the Plans and Pricing
|Title:||Pyridyl substituted aminoalkyl-thioureas and ureas|
|Abstract:||The compounds are pyridyl substituted aminoalkylthioureas and ureas which are inhibitors of H-2 histamine receptors. A compound of this invention is N-methyl-N'-[2-(2-pyridylmethylamino)ethyl]thiourea.|
|Inventor(s):||Durant; Graham John (Welwyn Garden City, EN), Emmett; John Colin (Codicote, EN), Ganellin; Charon Robin (Welwyn Garden City, EN)|
|Assignee:||Smith Kline & French Laboratories, Inc. (Welwyn Garden City, EN)|
|Filing Date:||Mar 13, 1974|
|Claims:||1. A compound of the formula: ##SPC5## |
wherein A is such that there is formed together with the carbon atom shown a pyridine ring; X.sub.1 is hydrogen, lower alkyl, hydroxyl, trifluoromethyl, halogen, amino or ##EQU4## X.sub.2 is hydrogen or when X.sub.1 is lower alkyl, lower alkyl or halogen; k is 1 or 2 and m is 2 or 3, provided that the sum of k and m is 3 or 4; Y is NH; E is oxygen or sulphur; R.sub.1 is hydrogen, lower alkyl or dimethylaminoethyl, or a pharmaceutically acceptable acid addition salt thereof.
2. A compound of claim 1 wherein k is 1 and m is 2.
3. A compound of claim 2 in which X.sub.1 is hydrogen, methyl, bromo, hydroxyl or amino and X.sub.2 is hydrogen; E is sulphur and R.sub.1 is methyl.
4. A compound of claim 1, said compound being N-methyl-N'-[2-(2-pyridylmethylamino)ethyl]thiourea.
Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verifification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.