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|Title:||Pyridyl substituted aminoalkyl-thioureas and ureas|
|Abstract:||The compounds are pyridyl substituted aminoalkylthioureas and ureas which are inhibitors of H-2 histamine receptors. A compound of this invention is N-methyl-N'-[2-(2-pyridylmethylamino)ethyl]thiourea.|
|Inventor(s):||Durant; Graham John (Welwyn Garden City, EN), Emmett; John Colin (Codicote, EN), Ganellin; Charon Robin (Welwyn Garden City, EN)|
|Assignee:||Smith Kline & French Laboratories, Inc. (Welwyn Garden City, EN)|
|Filing Date:||Mar 13, 1974|
|Claims:||1. A compound of the formula: ##SPC5## |
wherein A is such that there is formed together with the carbon atom shown a pyridine ring; X.sub.1 is hydrogen, lower alkyl, hydroxyl, trifluoromethyl, halogen, amino or ##EQU4## X.sub.2 is hydrogen or when X.sub.1 is lower alkyl, lower alkyl or halogen; k is 1 or 2 and m is 2 or 3, provided that the sum of k and m is 3 or 4; Y is NH; E is oxygen or sulphur; R.sub.1 is hydrogen, lower alkyl or dimethylaminoethyl, or a pharmaceutically acceptable acid addition salt thereof.
2. A compound of claim 1 wherein k is 1 and m is 2.
3. A compound of claim 2 in which X.sub.1 is hydrogen, methyl, bromo, hydroxyl or amino and X.sub.2 is hydrogen; E is sulphur and R.sub.1 is methyl.
4. A compound of claim 1, said compound being N-methyl-N'-[2-(2-pyridylmethylamino)ethyl]thiourea.