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Details for Patent: 3,931,268

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Details for Patent: 3,931,268

Title: Methylhydrazinomethyl-substituted benzoic acid amides
Abstract:Benzene-ring substituted (2-methylhydrazino)methylbenzene compounds and intermediates therefor are described. The former compounds are useful as cytostatic agents.
Inventor(s): Bollag; Werner (Basel, CH), Gutmann; Hugo (Reinach, CH), Hegedus; Balthasar (Binningen, CH), Kaiser; Ado (Neu-Frenkendorf, CH), Langemann; Albert (Binningen, CH), Muller; Marcel (Frenkendorf, CH), Zeller; Paul (Allschwil, CH)
Assignee: Hoffmann-La Roche Inc. (Nutley, NJ)
Filing Date:May 06, 1970
Application Number:05/035,292
Claims:1. A compound selected from the group consisting of compounds of the formula ##SPC5##

and pharmaceutically acceptable acid addition salts thereof; wherein R.sub.4 is hydrogen and R.sub.5 is selected from the group consisting of hydroxy-lower alkyl, (2-methylhydrazinomethyl)phenyl, hydrogen, lower alkoxy-lower alkyl, cyclo-lower alkyl, and cyano-lower alkyl.

2. A compound as in claim 1 which is 4-[(2-methylhydrazino)methyl]-benzamide.

3. A compound as in claim 1 which is 4-[(2-methylhydrazino)methyl]-benzoic acid (3-methoxypropyl)-amide.

4. A compound as in claim 1 which is 4-[(2-methylhydrazino)methyl]-benzoic acid (2-cyanoethyl)-amide.

5. A compound as in claim 1 which is 4-[(2-methylhydrazino)methyl]-benzoic acid cyclopropylamide.

6. A compound as in claim 1 which is 4,4'-bis-[(2-methylhydrazino)-methyl]-benzanilide.

7. A compound as in claim 1 of the formula ##SPC6##

8. A compound as in claim 7 which is 4-[(2-methylhydrazino)methyl]-benzoic acid (2-hydroxyethyl)-amide.
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