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Details for Patent: 3,927,216

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Details for Patent: 3,927,216

Title: 1,2,4-Triazol E-3-carboxamides for inhibiting virus infections
Abstract:The use of 1,2,4-triazole-3-carboxamide and 1,2,4-triazole-3-thiocarboxamide and physiologically compatible salts thereof for inhibiting the development of influenza, parainfluenza, and herpes virus infections in warm blooded animals and rhino, measles and vaccinia virus in cell cultures as antiviral agents is disclosed. A process for synthesizing 1-.beta.-D-ribofuranosyl-1,2,4-triazole-3-carboxamide is also disclosed.
Inventor(s): Witkowski; Joseph T. (Laguna Niguel, CA), Robins; Roland K. (Santa Ana, CA)
Assignee: ICN Pharmaceuticals, Inc. (Irvine, CA)
Filing Date:Mar 12, 1973
Application Number:05/340,332
Claims:1. A process of inhibiting the development of influenza, parainfluenza and herpes virus infections in warm blooded animals comprising administering to said warm blooded animals an effective amount of a composition containing from about 0.001 to about 10% by weight, based on the total weight of the composition of a compound of the structure: ##SPC2##

wherein X is O or S, and Y is H or an alkalai metal.

2. The process of claim 1 wherein the effective amount is about 32 micrograms of said compound per mililiter.

3. A process of inhibiting the developement of rhino, measles and vaccinia virus in cell culture comprising contacting the virus in said cell culture with a composition containing from about 0.001 to about 10% by weight, based on the total weight of the composition of a compound of the structure: ##SPC3##

wherein X is O or S and Y is H or an alkalai metal.

4. A composition effective for inhibiting the development of influenza, parainfluenza and herpes virus infections in warm blooded animals comprising from about .001 to about 10% by weight, based on the total weight of said composition of a compound of the structure: ##SPC4##

wherein X is O or S and Y is H or an alkalai metal in a pharmaceutical carrier.

5. The composition of claim 4 in which the carrier is selected from the group consisting of ointment, cream, topical solution, and suppository, and said compound is present in a quantity of from about 0.025 to about 1% by weight, based on the total weight of the composition.

6. The composition of claim 5 in which said compound is present in a quantity of from about 0.025 to about 0.1% by weight based on the total weight of the composition.

7. The composition of claim 4 in which said carrier is a liquified propellant and said compound is a powder having a particle size from about 0.5 to about 25 microns.

8. The composition of claim 7 in which the particle size is from about 0.5 to about 4 microns.

9. The composition of claim 7 in which said composition includes from about 0.1 to about 5% by weight, based on the total weight of the composition of a surface active agent.

10. The composition of claim 4 in which said carrier is a physiological saline solution containing from about 10 to about 500 miligrams per mililiter of solution of said compound.

11. The composition of claim 4 in which said carrier is an oral preparation in tablet or capsule form containing from about 10 to about 500 milligrams per tablet or capsule of said compound.
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