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Serving hundreds of leading biopharmaceutical companies globally:

Johnson and Johnson
Harvard Business School
US Department of Justice

Generated: June 25, 2018

DrugPatentWatch Database Preview

Details for Patent: 3,914,412

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Title: [Des--Gly] 10 -Gn--RH nonapeptide amide analogs in position 6 having ovulation-inducing activity
Abstract:An unnatural nonapeptide with improved biological activities surpassing those of the natural follicle-stimulating luteinizing hormone-releasing hormone (Gn--RH) is described. The new peptide induces ovulation in warm-blooded animals at an oral dose of 5 - 100 .mu.g./kg.
Inventor(s): Gendrich; Ronald Lee (Waukegan, IL), Rippel; Riemond Henry (Gurnee, IL), Seely; John Hunter (Lake Bluff, IL)
Assignee: Abbott Laboratories (North Chicago, IL)
Filing Date:Oct 11, 1973
Application Number:05/405,334
Claims:1. The process of inducing ovulation in a warm-blooded animal possessing a suitably mature follicle comprising administering to said animal a dose sufficient to induce ovulation of a compound of claim 1 the formula:

wherein all aminoacids are present in their optical L-configuration and wherein X represents an aminoacid in the D-configuration and having the formula: ##EQU2## wherein R is a linear or branched hydrocarbon chain of 1 - 4 carbon atoms.

2. The process of claim 1 wherein said dose is administered orally and contains between 2 and 100 .mu.g./kg. of said compound.

3. The process of claim 1 wherein said dose is administered parenterally and contains between 0.02 and 1.0 .mu.g./kg. of said compound.

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Serving hundreds of leading biopharmaceutical companies globally:

Farmers Insurance
Cantor Fitzgerald
Chinese Patent Office
Johnson and Johnson

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