|Title:|| [Des--Gly] 10 -Gn--RH nonapeptide amide analogs in position 6 having ovulation-inducing activity|
|Abstract:||An unnatural nonapeptide with improved biological activities surpassing those of the natural follicle-stimulating luteinizing hormone-releasing hormone (Gn--RH) is described. The new peptide induces ovulation in warm-blooded animals at an oral dose of 5 - 100 .mu.g./kg.|
|Inventor(s):|| Gendrich; Ronald Lee (Waukegan, IL), Rippel; Riemond Henry (Gurnee, IL), Seely; John Hunter (Lake Bluff, IL) |
|Assignee:|| Abbott Laboratories (North Chicago, IL) |
|Filing Date:||Oct 11, 1973|
|Claims:||1. The process of inducing ovulation in a warm-blooded animal possessing a suitably mature follicle comprising administering to said animal a dose sufficient to induce ovulation of a compound of claim 1 the formula: |
wherein all aminoacids are present in their optical L-configuration and wherein X represents an aminoacid in the D-configuration and having the formula: ##EQU2## wherein R is a linear or branched hydrocarbon chain of 1 - 4 carbon atoms.
2. The process of claim 1 wherein said dose is administered orally and contains between 2 and 100 .mu.g./kg. of said compound.
3. The process of claim 1 wherein said dose is administered parenterally and contains between 0.02 and 1.0 .mu.g./kg. of said compound.