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Details for Patent: 3,914,286

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Details for Patent: 3,914,286

Title: Lower alkyl esters of p-benzoylphenoxy isobutyric acid
Abstract:Derivatives of p-alkyl-carbonyl-phenoxy-alkyl- and carboxy-phenoxy-alkyl-carboxylic acids complying to the general formula: ##EQU1## where R represents --H, NH.sub.2 ; (--CH.sub.3 C.sub.2 H.sub.5, C.sub.3 H.sub.7, or the .omega. halogen derivatives of these groups); C.sub.6 H.sub.5 ; --OH, --OCH.sub.3, OC.sub.2 H.sub.5, NHOH or ##EQU2## where R.sub.1 and R.sub.2 can be linear radicals such as --CH.sub.3 or --CH.sub.2 --CH.sub.3 or can be a ring such as that of piperidine, methyl-2-piperidine, piperazine, morpholine, pyrrolidine, methyl-4-piperidine, N-phenyl-piperazine, N-p-methoxy-phenyl-piperazine, N-methyl-4-piperazine, N-p-chlorophenyl-piperazine or hexamethyleneimine or ethylamino-ethyl-amine; X represents =O or =N--O--H; R--C-- represents --C.tbd.N; n is 0, 1, 2 or 3 normal or iso when R' is --H and N is 1, 2, 3 when R' is --C.sub.6 H.sub.5 ; R' represents --H or C.sub.6 H.sub.5 ; and Y represents --OH --OCH.sub.3 ; --OC.sub.2 H.sub.5 ; NHOH or ##EQU3## where R.sub.1 and R.sub.2 can be linear radicals such as --CH.sub.3 or --CH.sub.2 --CH.sub.3 or can be represented by a ring such as that of piperidine, methyl-2-piperidine, piperazine, morpholine, pyrrolidine, methyl-4-piperidine, N-phenyl-piperazine, N-p-methoxy-phenyl-piperazine, N-methyl-4-piperazine, N-p-chlorophenyl-piperazine or hexamethyl-eneimine or ethylamino-ethyl-amine. These compounds have neurotrope, anti-inflammatory and normo-lipid activity.
Inventor(s): Mieville; Andre (Lausanne, CH)
Assignee: Orchimed S.A. (CH)
Filing Date:Feb 02, 1970
Application Number:05/008,071
Claims:1. A phenoxy compound which is a methyl, ethyl or propyl ester of p-benzoylphenoxy-isobutyric acid.

2. A compound according to claim 1 which is the ethyl ester of p-benzoylphenoxy-isobutyric acid.
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