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|Title:||Basically substituted heterocycles as anti-emetics|
|Abstract:||Certain 11-basically substituted dibenzo?b,f!-?1,4!thiazepines and dibenzo?b,e! ?1,4!diazepines are useful as anti-emetics.|
|Inventor(s):||Schmutz; Jean (Muri, CH), Hunziker; Fritz (Bern, CH)|
|Assignee:||Wander; Dr. A. (Bern, CH)|
|Filing Date:||Jan 22, 1974|
|Claims:||1. A method for treating emesis, which comprises enterally or parenterally administering to a mammal in need of said treatment an anti-emetic effective amount of a compound of the formula: ##EQU12## and pharmaceutically acceptable acid additional salts thereof, where Z denotes sulphur, R.sub.1 represents hydrogen, allyl, alkyl containing not more than 3 carbon atoms, hydroxyalkyl containing not more than 3 carbon atoms, alkoxyalkyl containing not more than 6 carbon atoms or alkoyloxyalkyl containing not more than 6 carbon atoms and R.sub.2 and R.sub.3 are the same or different and represent hydrogen or methyl. |
2. A method according to claim 1 in which the compound is 2-dimethylaminosulphonyl-11-(4-methyl-1-piperazinyl)-dibenzo?b,f!?1,4!-thi azepine.
3. A method according to claim 1 wherein the compound is administered to a mammal in need of said treatment at a daily dose of from about 5 milligrams to about 400 milligrams.
4. A method according to claim 1 wherein the compound is administered to a mammal in need of said treatment in a unit dosage form comprising said compound to the extent of from about 10 milligrams to about 25 milligrams per unit dosage.
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