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Generated: May 24, 2018

DrugPatentWatch Database Preview

Details for Patent: 3,907,801

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Title: N-?(4-pyridyl-piperazino)-alkyl!-azaspiroalkanediones
Abstract:The present invention concerns the class of heterocyclic carbon compounds comprised of N-(heteroarcyclic)piperazinylalkyl derivatives of azaspiroalkanediones which have potent and specific tranquilizing action and anti-emetic properties. Typical embodiments of this invention are 8-?4-?4-(2-pyrimidinyl)-1-piperazinyl!butyl!-8-azaspiro?4.5!decane-7,9-dio ne and 8-?4-?4-(2-pyridyl)-1-piperazinyl!-butyl!-8-azaspiro?4.5!decane-7,9-dione.
Inventor(s): Wu; Yao Hua (Evansville, IN), Rayburn; James W. (Evansville, IN)
Assignee: Mead Johnson and Company (Evansville, IN)
Filing Date:Dec 06, 1972
Application Number:05/312,543
Claims:1. A compound selected from the group consisting of a compound having the formula ##SPC12##


n is the integer 4 or 5;

A is a divalent straight or branched alkylene chain of 2 to 6 carbon atoms inclusive and connects the nitrogen atoms as shown through at least 2 carbon atoms;

B is a group having the formula ##SPC13##

wherein one of W and Y is CH and the other is nitrogen and R.sup.1 and R.sup.2 are independently selected from the group consisting of hydrogen, lower alkyl of from 1 to 4 carbon atoms inclusive, and lower alkoxy of from 1 to 4 carbon atoms inclusive;

and the non-toxic pharmaceutically acceptable acid addition salts thereof.

2. The compound 8-?4-?4-(2-pyridyl)-1-piperazinyl!butyl!-8-azaspiro?4.5!decane-7,9-dione as recited in claim 1.

3. The compound 8-?4-?4-(2-pyridyl)-1-piperazinyl!butyl!-8-azaspiro?4.5!decane-7,9-dione hydrochloride as recited in claim 1.

4. The compound 8-?2-?4-(2-pyridyl)-1-piperazinyl!ethyl!-8-azaspiro?4.5!decane-7,9-dione as recited in claim 1.

5. The compound 8-?2-?4-(2-pyridyl)-1-piperazinyl!ethyl!-8-azaspiro?4.5!decane-7,9-dione hydrochloride as recited in claim 1.

6. The compound 8-?3-?4-(6-methoxy-2-pyridyl)-1-piperazinyl!-propyl!-8-azaspiro?4.5!decane -7,9-dione as recited in claim 1.

7. The compound 8-?3-?4-(6-methoxy-2-pyridyl)-1-piperazinyl!-propyl!-8-azaspiro?4.5!decane -7,9-dione hydrochloride as recited in claim 1.

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Serving hundreds of leading biopharmaceutical companies globally:

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Cantor Fitzgerald

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