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|Title:||Use of prostaglandins E and F for prevention of pregnancy in humans|
|Abstract:||Methods and compositions are disclosed for administering prostaglandins of the PGF and PGE types to ovulating humans for the prevention of pregnancy.|
|Inventor(s):||Pharriss; Bruce B. (Kalamazoo, MI)|
|Assignee:||The Upjohn Company (Kalamazoo, MI)|
|Filing Date:||Feb 07, 1973|
|Claims:||1. A method of preventing pregnancy in an ovulating human which consists essentially of providing to a said human in a span of time beginning at or about the time of ovulation and ending at or about the time of next expected heat or menses an effective amount for preventing pregnancy of a member selected from the group consisting of the free acids, pharmaceutically acceptable salts, and alkyl esters having one to 6 carbon atoms, inclusive, in the alkyl portion, of a compound represented by the formula ##SPC6## |
wherein W is =C=O or ##SPC7##
X is CH.sub.2 CH.sub.2 or trans CH=CH and both Y and Z are CH.sub.2 CH.sub.2 ; X is trans CH=CH, Y is cis CH=CH and Z is CH.sub.2 CH.sub.2 or cis CH=CH; m is 0, 1 or 2 and n is 2, 3, 4 or 5, in a dosage unit form compounded with pharmaceutical means which adapt the form for systemic administration.
2. A method according to claim 1 wherein W is =C=O.
3. A method according to claim 1 wherein said member is PGE.sub.2.
4. A method according to claim 1 wherein said member is PGE.sub.2 in salt form.
5. A method according to claim 1 wherein said member is PGE.sub.2 in alkyl ester form.
6. A method according to claim 1 wherein W is ##SPC8##
7. A method according to claim 1 wherein said member is PGF.sub.2 .alpha..
8. A method according to claim 1 wherein said member is PGF.sub.2 .alpha. in salt form.
9. A method according to claim 1 wherein said member is PGF.sub.2 .alpha. in alkyl ester form.
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