Generated: April 23, 2017
|Title:||Process of preparing 1,4-diloweralkyl-3-loweralkoxy-carbonyl-2-acetates|
|Abstract:||The compounds are of the class of 5-aroyl-pyrrole alkenoic acids and corresponding acid derivatives thereof useful as anti-inflammatory agents and as synthetic intermediates.|
|Inventor(s):||Carson; John Robert (Norristown, PA)|
|Assignee:||McNeil Laboratories, Inc. (Fort Washington, PA)|
|Filing Date:||Feb 16, 1973|
|Claims:||1. The process of making a loweralkyl 1,4-diloweralkyl-3-loweralkoxycarbonyl-pyrrole-2-acetate of the formula: ##SPC13## |
which comprises reacting at just below 60.degree.C a mixture of a loweralkylamine of the formula: R.sub.4 --NH.sub.2 and a di-loweralkyl acetone dicarboxylate of the formula: ##SPC14##
with a chloromethyl loweralkyl ketone of the formula: Cl--CH.sub.2 --CO--R.sub.5, wherein the foregoing formulas said R.sub.4 and said R.sub.5 represent lower alkyl.
2. The process of claim 1 wherein said dicarboxylate is diethyl acetone dicarboxylate.
3. The process of claim 1 wherein said dicarboxylate is diethyl acetone dicarboxylate and said loweralkylamine is methylamine.
4. The process of claim 1 wherein said dicarboxylate is diethyl acetone dicarboxylate, said loweralkylamine is methylamine and said ketone is 1-chloro-2-butanone.
5. The process of claim 1 wherein said dicarboxylate is diethyl acetone dicarboxylate, said loweralkylamine is methylamine and said ketone is chloroacetone.
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