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Details for Patent: 3,862,175

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Details for Patent: 3,862,175

Title: BIS-CHROMONE COMPOUNDS
Abstract:Compounds of the formula ##SPC1## Wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5 and R.sup.6 are each selected from hydrogen, halogen, hydroxy, lower alkyl, lower alkoxy, hydroxy lower alkyl, halo lower alkyl, hydroxy lower alkoxy and lower alkoxy lower alkoxy, X is selected from straight and branched, saturated and unsaturated hydrocarbon chains which are uninterrupted or interrupted by a member from the group of benzene, oxygen, and carbonyl and are unsubstituted or substituted by a member of the group of halogen, hydroxy and lower alkoxy, and YZ and Y'Z' are selected from ##SPC2## Wherein W represents carboxylic acid or functional derivatives or groups convertible thereto, with the proviso that YZ and Y'Z' are not both simultaneously the chain ##SPC3## The compounds are intermediates in the production of compounds useful as inhibitors of certain antigen-antibody reactions.
Inventor(s): Fitzmaurice; Colin (Macclesfield, EN), Lee; Thomas Brian (Loughborough, EN)
Assignee: Fison House (London, EN)
Filing Date:Jul 19, 1972
Application Number:05/273,169
Claims:1. A compound of the formula ##SPC47##

wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5 and R.sup.6 are each selected from the group consisting of hydrogen, halogen, hydroxy, lower alkyl, lower alkoxy, hydroxy lower alkyl, halo lower alkyl, hydroxy lower alkoxy and lower alkoxy lower alkoxy and X is selected from the group consisting of straight and branched, saturated and unsaturated hydrocarbon chains of 1 to 12 carbon atoms which are uninterrupted or interrupted by a member selected from the group consisting of benzene, oxygen and carbonyl and are unsubstituted or substituted by a member of the group consisting of halogen, hydroxy and lower alkoxy, and YZ and Y'Z' are selected from the groups ##SPC48##

and ##SPC49##

in which W is selected from the group consisting of carboxy, and therapeutically acceptable salts, esters and amides thereof, and nitrile, methyl, hydroxymethyl, halomethyl, formyl, acetyl, vinyl and styryl, providing that YZ and Y'Z' are not both simultaneously the chain ##SPC50##

or a therapeutically acceptable salt, ester or amide thereof.

2. A compound of the formula ##SPC51##

wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5 and R.sup.6 are each selected from the group consisting of hydrogen, halogen, hydroxy, lower alkyl, lower alkoxy, hydroxy lower alkyl, halo lower alkyl, hydroxy lower alkoxy and lower alkoxy lower alkoxy and X is selected from the group consisting of straight and branched saturated and unsaturated hydrocarbon chains of 1 to 12 carbon atoms which are uninterrupted or interrupted by a member selected from the group consisting of benzene, oxygen and carbonyl and are unsubstituted or substituted by a member of the group consisting of halogen, hydroxy and lower alkoxy, and V is selected from the group consisting of nitrile, methyl, hydroxymethyl, halomethyl, formyl, acetyl, vinyl and styryl.

3. A compound of the formula ##SPC52##

wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5 and R.sup.6 are each selected from the group consisting of hydrogen, halogen, hydroxy, lower alkyl, lower alkoxy, hydroxy lower alkyl, halo lower alkyl, hydroxy lower alkoxy and lower alkoxy lower alkoxy and X is selected from the group consisting of straight and branched, saturated and unsaturated hydrocarbon chains of 1 to 12 carbon atoms, which are uninterrupted or interrupted by a member selected from the group consisting of benzene, oxygen and carbonyl and are unsubstituted or substituted by a member of the group consisting of halogen, hydroxy and lower alkoxy, and V is selected from the group consisting of nitrile, methyl, hydroxymethyl, halomethyl, formyl, acetyl, vinyl and styryl.

4. A compound of the formula ##SPC53##

in which V is selected from the group consisting of nitrile, methyl, hydroxymethyl, halomethyl, formyl, acetyl, vinyl and styryl.
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