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Details for Patent: 3,855,270

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Details for Patent: 3,855,270

Title: 15-ALKYL PROSTAGLANDINS F .sub..alpha.
Abstract:Prostaglandin E.sub.1 -type and F.sub.1 -type compounds with a methyl or an ethyl substituent at the C-15 position are disclosed. These are useful for the same pharmacological purposes as the unsubstituted prostaglandins.
Inventor(s): Pike; John E. (Kalamazoo, MI), Schneider; William P. (Kalamazoo Township, Kalamazoo County, MI)
Assignee: The Upjohn Company (Kalamazoo, MI)
Filing Date:Sep 13, 1972
Application Number:05/288,618
Claims:1. An optically active compound of the formula: ##SPC14##

or a racemic compound of that formula and the mirror image thereof, wherein R.sub.1 is hydrogen, alkyl of one to 8 carbon atoms, inclusive, or a pharmacologically acceptable cation, and wherein R.sub.2 is methyl or ethyl.

2. An optically active compound according to claim 1.

3. 15-Methyl-PGF.sub.1.sub..alpha., an optically active compound according to claim 2 wherein R.sub.1 is hydrogen and R.sub.2 is methyl.

4. 15-Methyl-PGF.sub.1.sub..alpha. methyl ester, an optically active compound according to claim 2 wherein R.sub.1 and R.sub.2 are both methyl.

5. Racemic 15-methyl-PGF.sub.1.sub..alpha., a racemic compound according to claim 1 wherein R.sub.1 is hydrogen and R.sub.2 is methyl.

6. Racemic 15-methyl-PGF.sub.1.sub..alpha. methyl ester, a racemic compound according to claim 1 wherein R.sub.1 and R.sub.2 are both methyl.
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